KLF4 (Entrez ID: 9314)

Entrez Gene ID 9314
Official Gene Symbol KLF4 (GeneCards)
Full name Kruppel like factor 4
Location 9q31.2
Other ids Vega : OTTHUMG00000020449
MIM : 602253
HGNC : HGNC:6348
Ensembl : ENSG00000136826
Other names EZF, GKLF
Summary This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Variants

Found 23 variants in this database.