| Entrez Gene ID | 9448 |
|---|---|
| Official Gene Symbol | MAP4K4 (GeneCards) |
| Full name | mitogen-activated protein kinase kinase kinase kinase 4 |
| Location | 2q11.2 |
| Other ids | Vega : OTTHUMG00000155394 MIM : 604666 HGNC : HGNC:6866 Ensembl : ENSG00000071054 |
| Other names | HGK, NIK, MEKKK4, FLH21957, HEL-S-31 |
| Summary | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
Found 4 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 973 | 9448 | MAP4K4 | 2 | 102448263 | 102448263 | Human Skin Fibroblasts | HiSeq 2500 |
| 3093 | 9448 | MAP4K4 | 2 | 102535055 | 102535055 | Asymptomatic | HiSeq 2500 HiSeq X Ten |
| 3237 | 9448 | MAP4K4 | 2 | 102430640 | 102430640 | Asymptomatic | HiSeq 2500 HiSeq X Ten |
| 25018 | 9448 | MAP4K4 | 2 | 102576216 | 102576216 | Asymptomatic | HiSeq 2500 HiSeq X Ten Single cell Sequencing Cell cloning |