| Entrez Gene ID |
9459 |
| Official Gene Symbol |
ARHGEF6 (GeneCards) |
| Full name |
Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Location |
Xq26.3 |
| Other ids |
Vega : OTTHUMG00000022518
MIM : 300267
HGNC : HGNC:685
Ensembl : ENSG00000129675
|
| Other names |
PIXA,
COOL2,
MRX46,
Cool-2,
alphaPIX,
alpha-PIX
|
| Summary |
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008] |