| Entrez Gene ID | 9732 |
|---|---|
| Official Gene Symbol | DOCK4 (GeneCards) |
| Full name | dedicator of cytokinesis 4 |
| Location | 7q31.1 |
| Other ids | Vega : OTTHUMG00000155077 MIM : 607679 HGNC : HGNC:19192 Ensembl : ENSG00000128512 |
| Other names | None |
| Summary | This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008] |
Found 8 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 10380 | 9732 | DOCK4 | 7 | 111429867 | 111429867 | Asymptomatic | HiSeq X Ten |
| 11114 | 9732 | DOCK4 | 7 | 111522834 | 111522834 | Asymptomatic | HiSeq X Ten |
| 11133 | 9732 | DOCK4 | 7 | 111497530 | 111497530 | Asymptomatic | HiSeq X Ten |
| 11175 | 9732 | DOCK4 | 7 | 111611244 | 111611244 | Asymptomatic | HiSeq X Ten |
| 11258 | 9732 | DOCK4 | 7 | 111807582 | 111807582 | Asymptomatic | HiSeq X Ten |
| 11412 | 9732 | DOCK4 | 7 | 111796536 | 111796536 | Cockayne syndrome | HiSeq X Ten |
| 11486 | 9732 | DOCK4 | 7 | 111722623 | 111722623 | Cockayne syndrome | HiSeq X Ten |
| 23276 | 9732 | DOCK4 | 7 | 111414421 | 111414421 | Asymptomatic | HiSeq X Ten Single cell Sequencing Cell cloning |