| Entrez Gene ID |
8935 (NCBI Gene) |
| Official Gene Symbol |
SKAP2 (GeneCards) |
| Number of variants in SKAP2 in this database |
6 (view all the variants) |
| Full name |
src kinase associated phosphoprotein 2 |
| Band |
7p15.2 |
| Other IDs |
Vega:
OTTHUMG00000023495
OMIM:
605215
HGNC:
HGNC:15687
Ensembl:
ENSG00000005020
|
| Other names |
PRAP,
RA70,
SAPS,
SCAP2,
SKAP55R,
SKAP-HOM
|
| Summary |
The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] |