| Entrez Gene ID |
3811 (NCBI Gene) |
| Official Gene Symbol |
KIR3DL1 (GeneCards) |
| Number of variants in KIR3DL1 in this database |
1 (view all the variants) |
| Full name |
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 |
| Band |
19q13.42 |
| Other IDs |
Vega:
OTTHUMG00000065933
OMIM:
604946
HGNC:
HGNC:6338
Ensembl:
ENSG00000167633
|
| Other names |
KIR,
NKB1,
NKAT3,
NKB1B,
NKAT-3,
CD158E1,
KIR3DL1/S1
|
| Summary |
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |