| Entrez Gene ID |
64581 (NCBI Gene) |
| Official Gene Symbol |
CLEC7A (GeneCards) |
| Number of variants in CLEC7A in this database |
2 (view all the variants) |
| Full name |
C-type lectin domain containing 7A |
| Band |
12p13.2 |
| Other IDs |
Vega:
OTTHUMG00000133597
OMIM:
606264
HGNC:
HGNC:14558
Ensembl:
ENSG00000172243
|
| Other names |
BGR,
CD369,
CANDF4,
SCARE2,
DECTIN1,
CLECSF12
|
| Summary |
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |