| Entrez Gene ID |
4481 (NCBI Gene) |
| Official Gene Symbol |
MSR1 (GeneCards) |
| Number of variants in MSR1 in this database |
13 (view all the variants) |
| Full name |
macrophage scavenger receptor 1 |
| Band |
8p22 |
| Other IDs |
Vega:
OTTHUMG00000094809
OMIM:
153622
HGNC:
HGNC:7376
Ensembl:
ENSG00000038945
|
| Other names |
SRA,
SR-A,
CD204,
SR-AI,
phSR1,
phSR2,
SCARA1,
SR-AII,
SR-AIII
|
| Summary |
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |