| Entrez Gene ID |
150 (NCBI Gene) |
| Official Gene Symbol |
ADRA2A (GeneCards) |
| Number of variants in ADRA2A in this database |
17 (view all the variants) |
| Full name |
adrenoceptor alpha 2A |
| Band |
10q25.2 |
| Other IDs |
Vega:
OTTHUMG00000019050
OMIM:
104210
HGNC:
HGNC:281
Ensembl:
ENSG00000150594
|
| Other names |
ADRA2,
ADRAR,
ZNF32,
ADRA2R,
ALPHA2AAR
|
| Summary |
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] |