| Entrez Gene ID |
1634 (NCBI Gene) |
| Official Gene Symbol |
DCN (GeneCards) |
| Number of variants in DCN in this database |
10 (view all the variants) |
| Full name |
decorin |
| Band |
12q21.33 |
| Other IDs |
Vega:
OTTHUMG00000169998
OMIM:
125255
HGNC:
HGNC:2705
Ensembl:
ENSG00000011465
|
| Other names |
CSCD,
PG40,
PGII,
PGS2,
DSPG2,
SLRR1B
|
| Summary |
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015] |