| Entrez Gene ID |
7799 (NCBI Gene) |
| Official Gene Symbol |
PRDM2 (GeneCards) |
| Number of variants in PRDM2 in this database |
8 (view all the variants) |
| Full name |
PR/SET domain 2 |
| Band |
1p36.21 |
| Other IDs |
Vega:
OTTHUMG00000007917
OMIM:
601196
HGNC:
HGNC:9347
Ensembl:
ENSG00000116731
|
| Other names |
RIZ,
KMT8,
RIZ1,
RIZ2,
KMT8A,
MTB-ZF,
HUMHOXY1
|
| Summary |
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |