| Entrez Gene ID |
3176 (NCBI Gene) |
| Official Gene Symbol |
HNMT (GeneCards) |
| Number of variants in HNMT in this database |
9 (view all the variants) |
| Full name |
histamine N-methyltransferase |
| Band |
2q22.1 |
| Other IDs |
Vega:
OTTHUMG00000131751
OMIM:
605238
HGNC:
HGNC:5028
Ensembl:
ENSG00000150540
|
| Other names |
HMT,
MRT51,
HNMT-S1,
HNMT-S2
|
| Summary |
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] |