| Entrez Gene ID |
55704 (NCBI Gene) |
| Official Gene Symbol |
CCDC88A (GeneCards) |
| Number of variants in CCDC88A in this database |
5 (view all the variants) |
| Full name |
coiled-coil domain containing 88A |
| Band |
2p16.1 |
| Other IDs |
Vega:
OTTHUMG00000151915
OMIM:
609736
HGNC:
HGNC:25523
Ensembl:
ENSG00000115355
|
| Other names |
APE,
GIV,
GRDN,
PEHO,
HkRP1,
PEHOL,
GIRDIN,
KIAA1212
|
| Summary |
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |