| Entrez Gene ID |
9448 (NCBI Gene) |
| Official Gene Symbol |
MAP4K4 (GeneCards) |
| Number of variants in MAP4K4 in this database |
4 (view all the variants) |
| Full name |
mitogen-activated protein kinase kinase kinase kinase 4 |
| Band |
2q11.2 |
| Other IDs |
Vega:
OTTHUMG00000155394
OMIM:
604666
HGNC:
HGNC:6866
Ensembl:
ENSG00000071054
|
| Other names |
HGK,
NIK,
MEKKK4,
FLH21957,
HEL-S-31
|
| Summary |
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |