| Entrez Gene ID |
7247 (NCBI Gene) |
| Official Gene Symbol |
TSN (GeneCards) |
| Number of variants in TSN in this database |
24 (view all the variants) |
| Full name |
translin |
| Band |
2q14.3 |
| Other IDs |
Vega:
OTTHUMG00000153334
OMIM:
600575
HGNC:
HGNC:12379
Ensembl:
ENSG00000211460
|
| Other names |
C3PO,
RCHF1,
TBRBP,
TRSLN,
BCLF-1,
REHF-1
|
| Summary |
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] |