| Entrez Gene ID |
5602 (NCBI Gene) |
| Official Gene Symbol |
MAPK10 (GeneCards) |
| Number of variants in MAPK10 in this database |
11 (view all the variants) |
| Full name |
mitogen-activated protein kinase 10 |
| Band |
4q21.3 |
| Other IDs |
Vega:
OTTHUMG00000130604
OMIM:
602897
HGNC:
HGNC:6872
Ensembl:
ENSG00000109339
|
| Other names |
JNK3,
JNK3A,
PRKM10,
SAPK1b,
p493F12,
p54bSAPK
|
| Summary |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] |