| Entrez Gene ID |
64094 (NCBI Gene) |
| Official Gene Symbol |
SMOC2 (GeneCards) |
| Number of variants in SMOC2 in this database |
16 (view all the variants) |
| Full name |
SPARC related modular calcium binding 2 |
| Band |
6q27 |
| Other IDs |
Vega:
OTTHUMG00000016050
OMIM:
607223
HGNC:
HGNC:20323
Ensembl:
ENSG00000112562
|
| Other names |
DTDP1,
SMAP2,
MST117,
MSTP117,
MSTP140,
bA37D8.1,
bA270C4A.1,
dJ421D16.1
|
| Summary |
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |