| Entrez Gene ID |
6885 (NCBI Gene) |
| Official Gene Symbol |
MAP3K7 (GeneCards) |
| Number of variants in MAP3K7 in this database |
10 (view all the variants) |
| Full name |
mitogen-activated protein kinase kinase kinase 7 |
| Band |
6q15 |
| Other IDs |
Vega:
OTTHUMG00000015217
OMIM:
602614
HGNC:
HGNC:6859
Ensembl:
ENSG00000135341
|
| Other names |
CSCF,
FMD2,
TAK1,
MEKK7,
TGF1a
|
| Summary |
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |