| Entrez Gene ID |
7991 (NCBI Gene) |
| Official Gene Symbol |
TUSC3 (GeneCards) |
| Number of variants in TUSC3 in this database |
10 (view all the variants) |
| Full name |
tumor suppressor candidate 3 |
| Band |
8p22 |
| Other IDs |
Vega:
OTTHUMG00000094803
OMIM:
601385
HGNC:
HGNC:30242
Ensembl:
ENSG00000104723
|
| Other names |
M33,
N33,
MRT7,
MRT22,
MagT2,
OST3A,
D8S1992
|
| Summary |
This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017] |