| Entrez Gene ID |
8644 (NCBI Gene) |
| Official Gene Symbol |
AKR1C3 (GeneCards) |
| Number of variants in AKR1C3 in this database |
3 (view all the variants) |
| Full name |
aldo-keto reductase family 1 member C3 |
| Band |
10p15.1 |
| Other IDs |
Vega:
OTTHUMG00000017585
OMIM:
603966
HGNC:
HGNC:386
Ensembl:
ENSG00000196139
|
| Other names |
DD3,
DDX,
PGFS,
HAKRB,
HAKRe,
HA1753,
HSD17B5,
hlPGFS
|
| Summary |
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |