| Entrez Gene ID |
960 (NCBI Gene) |
| Official Gene Symbol |
CD44 (GeneCards) |
| Number of variants in CD44 in this database |
4 (view all the variants) |
| Full name |
CD44 molecule (Indian blood group) |
| Band |
11p13 |
| Other IDs |
Vega:
OTTHUMG00000044388
OMIM:
107269
HGNC:
HGNC:1681
Ensembl:
ENSG00000026508
|
| Other names |
IN,
LHR,
MC56,
MDU2,
MDU3,
MIC4,
Pgp1,
CDW44,
CSPG8,
HCELL,
HUTCH-I,
ECMR-III
|
| Summary |
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] |