| Entrez Gene ID |
11096 (NCBI Gene) |
| Official Gene Symbol |
ADAMTS5 (GeneCards) |
| Number of variants in ADAMTS5 in this database |
11 (view all the variants) |
| Full name |
ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| Band |
21q21.3 |
| Other IDs |
Vega:
OTTHUMG00000078686
OMIM:
605007
HGNC:
HGNC:221
Ensembl:
ENSG00000154736
|
| Other names |
ADMP-2,
ADAM-TS5,
ADAMTS-5,
ADAMTS11,
ADAM-TS5,
ADAMTS-11,
ADAM-TS11
|
| Summary |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |