| Entrez Gene ID |
861 (NCBI Gene) |
| Official Gene Symbol |
RUNX1 (GeneCards) |
| Number of variants in RUNX1 in this database |
3 (view all the variants) |
| Full name |
runt related transcription factor 1 |
| Band |
21q22.12 |
| Other IDs |
Vega:
OTTHUMG00000086299
OMIM:
151385
HGNC:
HGNC:10471
Ensembl:
ENSG00000159216
|
| Other names |
AML1,
CBFA2,
EVI-1,
AMLCR1,
PEBP2aB,
CBF2alpha,
AML1-EVI-1,
PEBP2alpha
|
| Summary |
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |