| Entrez Gene ID |
23641 (NCBI Gene) |
| Official Gene Symbol |
LDOC1 (GeneCards) |
| Number of variants in LDOC1 in this database |
2 (view all the variants) |
| Full name |
LDOC1, regulator of NFKB signaling |
| Band |
Xq27.1 |
| Other IDs |
Vega:
OTTHUMG00000022558
OMIM:
300402
HGNC:
HGNC:6548
Ensembl:
ENSG00000182195
|
| Other names |
Mar7,
RTL7,
BCUR1,
Mart7,
SIRH7
|
| Summary |
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008] |