Gene Symbol:	ADA ( - )
Gene Full Name:	adenosine deaminase
Band:	20q13.12
Quick Links	Entrez ID:100; OMIM: 608958; Uniprot ID:ADA_HUMAN; ENSEMBL ID: ENSG00000196839; HGNC ID: 186
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005615	IEA	-	extracellular space	-
GO:0005764	IDA	-	lysosome	8452534
GO:0005829	TAS	-	cytosol	-
GO:0009897	IDA	-	external side of plasma membrane	7759315
GO:0009986	IDA	-	cell surface	7594462
GO:0016020	IDA	-	membrane	11999881
GO:0030054	IEA	-	cell junction	-
GO:0032839	IEA	-	dendrite cytoplasm	-
GO:0043025	IEA	-	neuronal cell body	-
GO:0060205	IEA	-	cytoplasmic vesicle lumen	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001883	IEA	-	purine nucleoside binding	-
GO:0004000	EXP	-	adenosine deaminase activity	3182793
GO:0004000	IDA	-	adenosine deaminase activity	3182793
GO:0004000	ISS	-	adenosine deaminase activity	-
GO:0005515	IPI	-	protein binding	7594462
GO:0008270	IMP	-	zinc ion binding	7599635
GO:0008270	ISS	-	zinc ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001666	IDA	-	response to hypoxia	16670267
GO:0001821	IEA	-	histamine secretion	-
GO:0001829	IEA	-	trophectodermal cell differentiation	-
GO:0001889	IEA	-	liver development	-
GO:0001890	IEA	-	placenta development	-
GO:0002314	IEA	-	germinal center B cell differentiation	-
GO:0002636	IEA	-	positive regulation of germinal center formation	-
GO:0002686	IEA	-	negative regulation of leukocyte migration	-
GO:0002906	IEA	-	negative regulation of mature B cell apoptotic process	-
GO:0006154	IDA	-	adenosine catabolic process	8894685
GO:0006154	ISS	-	adenosine catabolic process	-
GO:0006157	IEA	-	deoxyadenosine catabolic process	-
GO:0007155	IEA	-	cell adhesion	-
GO:0007568	IEA	-	aging	-
GO:0009168	IEA	-	purine ribonucleoside monophosphate biosynthetic process	-
GO:0010460	IEA	-	positive regulation of heart rate	-
GO:0030890	IEA	-	positive regulation of B cell proliferation	-
GO:0032261	IMP	-	purine nucleotide salvage	9361033
GO:0033089	IEA	-	positive regulation of T cell differentiation in thymus	-
GO:0033197	IEA	-	response to vitamin E	-
GO:0033632	IDA	-	regulation of cell-cell adhesion mediated by integrin	11772392
GO:0042110	IDA	-	T cell activation	7594462
GO:0042323	IEA	-	negative regulation of circadian sleep/wake cycle, non-REM sleep	-
GO:0042493	IEA	-	response to drug	-
GO:0042542	IEA	-	response to hydrogen peroxide	-
GO:0043101	TAS	-	purine-containing compound salvage	-
GO:0043278	IEA	-	response to morphine	-
GO:0045987	IEA	-	positive regulation of smooth muscle contraction	-
GO:0046061	IEA	-	dATP catabolic process	-
GO:0046101	IEA	-	hypoxanthine biosynthetic process	-
GO:0046103	IDA	-	inosine biosynthetic process	8894685
GO:0046103	ISS	-	inosine biosynthetic process	-
GO:0046111	IEA	-	xanthine biosynthetic process	-
GO:0046638	IEA	-	positive regulation of alpha-beta T cell differentiation	-
GO:0048286	IEA	-	lung alveolus development	-
GO:0048541	IEA	-	Peyer's patch development	-
GO:0048566	IEA	-	embryonic digestive tract development	-
GO:0050728	IEA	-	negative regulation of inflammatory response	-
GO:0050850	IEA	-	positive regulation of calcium-mediated signaling	-
GO:0050862	IEA	-	positive regulation of T cell receptor signaling pathway	-
GO:0060169	IDA	-	negative regulation of adenosine receptor signaling pathway	16670267
GO:0060407	IEA	-	negative regulation of penile erection	-
GO:0070244	IEA	-	negative regulation of thymocyte apoptotic process	-
GO:0070256	IEA	-	negative regulation of mucus secretion	-

Gene Symbol	Interactant	Interaction ID	References	Description
NR3C1	ADA	109165	9154805	Reconstituted Complex
NR3C1	ADA	106614	9154805	Reconstituted Complex
ADORA2A	ADA	106647	11125033	Affinity Capture-Western
ADORA2A	ADA	106614	11125033	Affinity Capture-Western
ADORA1	ADA	106646	12150791	Co-localization
ADORA1	ADA	106614	12150791	Co-localization
DRD1	ADA	106614	12150791	Co-localization
DRD1	ADA	108146	12150791	Co-localization

AutismKB 2.0

Annotation Details for ADA