AutismKB 2.0

Annotation Details for CDH2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDH2 ( CD325,CDHN,CDw325,NCAD )
Gene Full Name: cadherin 2, type 1, N-cadherin (neuronal)
Band: 18q12.1
Quick LinksEntrez ID:1000; OMIM: 114020; Uniprot ID:CADH2_HUMAN; ENSEMBL ID: ENSG00000170558; HGNC ID: 1759
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm22467863
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005886IDA-plasma membrane22467863
GO:0005886TAS-plasma membrane-
GO:0005911IDA-cell-cell junction7650039
GO:0005913IDA-cell-cell adherens junction19101069
GO:0005916IEA-fascia adherens-
GO:0005925IDA-focal adhesion21423176
GO:0009986ISS-cell surface-
GO:0014069IEA-postsynaptic density-
GO:0014704ISS-intercalated disc-
GO:0016021IEA-integral component of membrane-
GO:0016323IEA-basolateral plasma membrane-
GO:0016324IEA-apical plasma membrane-
GO:0016342IDA-catenin complex7650039
GO:0030027IDA-lamellipodium24046456
GO:0030054IDA-cell junction28169360
GO:0030864IDAcolocalizes_withcortical actin cytoskeleton24046456
GO:0042383IEA-sarcolemma-
GO:0044853IEA-plasma membrane raft-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding17057644
GO:0008013TAS-beta-catenin binding16344550
GO:0019901IEA-protein kinase binding-
GO:0019903IEA-protein phosphatase binding-
GO:0045294IPI-alpha-catenin binding7650039
GO:0045295IPI-gamma-catenin binding7650039
GO ID Evidence Qualifier GO_term References
GO:0007155TAS-cell adhesion2384753
GO:0007156IEA-homophilic cell adhesion via plasma membrane adhesion molecules-
GO:0007157IEA-heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-
GO:0010001ISS-glial cell differentiation-
GO:0016339IEA-calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-
GO:0016477IEA-cell migration-
GO:0021987IEA-cerebral cortex development-
GO:0034332TAS-adherens junction organization-
GO:0043410IEA-positive regulation of MAPK cascade-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0044331ISS-cell-cell adhesion mediated by cadherin-
GO:0048514IEA-blood vessel morphogenesis-
GO:0048854IEA-brain morphogenesis-
GO:0048872IEA-homeostasis of number of cells-
GO:0051146IEA-striated muscle cell differentiation-
GO:0051149TAS-positive regulation of muscle cell differentiation-
GO:0060019IEA-radial glial cell differentiation-
GO:0060563IEA-neuroepithelial cell differentiation-
GO:0070445IEA-regulation of oligodendrocyte progenitor proliferation-
GO:0090002IEA-establishment of protein localization to plasma membrane-
GO:0090090IEA-negative regulation of canonical Wnt signaling pathway-
GO:0097118IEA-neuroligin clustering involved in postsynaptic membrane assembly-
GO:0097150ISS-neuronal stem cell population maintenance-
GO:1902897IEA-regulation of postsynaptic density protein 95 clustering-
GO:2000809IEA-positive regulation of synaptic vesicle clustering-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDH2ACTA110657312438242 Affinity Capture-Western
CDH2ACTA110743512438242 Affinity Capture-Western
JUPCDH21099317650039 14625392 Affinity Capture-MS; Affinity Capture-Western
JUPCDH21074357650039 14625392 Affinity Capture-MS; Affinity Capture-Western
CDH4CDH210743510662782 Affinity Capture-Western
CDH4CDH210743710662782 Affinity Capture-Western
GNA13CDH210743511136230 Reconstituted Complex
GNA13CDH211591411136230 Reconstituted Complex
GNA12CDH210743511136230 Reconstituted Complex
GNA12CDH210903011136230 Reconstituted Complex
LRRC7CDH210743511729199 Affinity Capture-Western; Reconstituted Complex
LRRC7CDH212161011729199 Affinity Capture-Western; Reconstituted Complex
CTNNB1CDH210743511835406 12604612 14625392 Affinity Capture-MS; Affinity Capture-Western
CTNNB1CDH210788011835406 12604612 14625392 Affinity Capture-MS; Affinity Capture-Western
CTNNA1CDH210743512604612 14625392 Affinity Capture-MS; Affinity Capture-Western
CTNNA1CDH210787612604612 14625392 Affinity Capture-MS; Affinity Capture-Western
CTNND1CDH210743512604612 14625392 Affinity Capture-MS; Affinity Capture-Western
CTNND1CDH210788112604612 14625392 Affinity Capture-MS; Affinity Capture-Western
PKP4CDH211407412615965 Two-hybrid
PKP4CDH210743512615965 Two-hybrid
CDONCDH210743512634428 Affinity Capture-Western
CDONCDH211916512634428 Affinity Capture-Western
BOCCDH210743512634428 Affinity Capture-Western
BOCCDH212485912634428 Affinity Capture-Western
RAB8BCDH210743512639940 Affinity Capture-Western
RAB8BCDH211971912639940 Affinity Capture-Western
CDH11CDH210743514625392 Affinity Capture-MS
CDH11CDH210744414625392 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
CDH2rs1041985, rs894679 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:88355
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-171'