AutismKB 2.0

Annotation Details for HDAC6


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Basic Information Top
Gene Symbol:HDAC6 ( FLJ16239,HD6 )
Gene Full Name: histone deacetylase 6
Band: Xp11.23
Quick LinksEntrez ID:10013; OMIM: 300272; Uniprot ID:HDAC6_HUMAN; ENSEMBL ID: ENSG00000094631; HGNC ID: 14064
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000118IDA-histone deacetylase complex11948178
GO:0005634ISS-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm24687993
GO:0005737ISS-cytoplasm11861901
GO:0005771TAS-multivesicular body25548531
GO:0005829ISS-cytosol-
GO:0005829TAS-cytosol-
GO:0005874IDA-microtubule12620231
GO:0005875IDA-microtubule associated complex19228685
GO:0005881IEA-cytoplasmic microtubule-
GO:0005901IDA-caveola18356165
GO:0016234IDA-inclusion body16192271
GO:0016235IDA-aggresome14675537
GO:0030286IDAcolocalizes_withdynein complex14675537
GO:0030424ISS-axon-
GO:0030425ISS-dendrite-
GO:0031252IDA-cell leading edge12024216
GO:0043204ISS-perikaryon-
GO:0048471IDA-perinuclear region of cytoplasm12024216
GO ID Evidence Qualifier GO_term References
GO:0001047IDA-core promoter binding24413532
GO:0003779IEA-actin binding-
GO:0004407IDA-histone deacetylase activity10220385
GO:0004407IMP-histone deacetylase activity23322205
GO:0005515IPI-protein binding16919237
GO:0008013IPI-beta-catenin binding18356165
GO:0008017IDA-microtubule binding19228685
GO:0008017ISS-microtubule binding-
GO:0008270IEA-zinc ion binding-
GO:0019899ISS-enzyme binding11861901
GO:0031593IDA-polyubiquitin binding14675537
GO:0031625IPI-ubiquitin protein ligase binding21753002
GO:0032041IEA-NAD-dependent histone deacetylase activity (H3-K14 specific)-
GO:0042826IPI-histone deacetylase binding12620231
GO:0042903IDA-tubulin deacetylase activity12620231
GO:0042903ISS-tubulin deacetylase activity-
GO:0042903TAS-tubulin deacetylase activity-
GO:0043014IDA-alpha-tubulin binding19228685
GO:0048156IDA-tau protein binding18636984
GO:0048487IEA-beta-tubulin binding-
GO:0051787EXP-misfolded protein binding17785525
GO:0051879IDA-Hsp90 protein binding15916966
GO:0070840IDA-dynein complex binding14675537
GO ID Evidence Qualifier GO_term References
GO:0000209IEA-protein polyubiquitination-
GO:0006351IEA-transcription, DNA-templated-
GO:0006476IMP-protein deacetylation15916966
GO:0006515IMP-misfolded or incompletely synthesized protein catabolic process14675537
GO:0006886IMP-intracellular protein transport16192271
GO:0006914IEA-autophagy-
GO:0007026IEA-negative regulation of microtubule depolymerization-
GO:0009636IMP-response to toxic substance19158084
GO:0009967IMP-positive regulation of signal transduction19158084
GO:0010033IMP-response to organic substance19158084
GO:0010469IMP-regulation of receptor activity19158084
GO:0010506TAS-regulation of autophagy25548531
GO:0010634IMP-positive regulation of epithelial cell migration12024216
GO:0010727IC-negative regulation of hydrogen peroxide metabolic process18606987
GO:0010870IMP-positive regulation of receptor biosynthetic process15916966
GO:0016241IMP-regulation of macroautophagy16192271
GO:0016575IDA-histone deacetylation10220385
GO:0016575ISS-histone deacetylation11861901
GO:0031647IMP-regulation of protein stability23580651
GO:0032418IMP-lysosome localization16192271
GO:0034983IMP-peptidyl-lysine deacetylation18356165
GO:0035967IMP-cellular response to topologically incorrect protein16192271
GO:0040029IMP-regulation of gene expression, epigenetic24413532
GO:0043162IEA-ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway-
GO:0043241IEA-protein complex disassembly-
GO:0043242IMP-negative regulation of protein complex disassembly15916966
GO:0045598IEA-regulation of fat cell differentiation-
GO:0045861IMP-negative regulation of proteolysis18356165
GO:0045892ISS-negative regulation of transcription, DNA-templated11861901
GO:0048668IEA-collateral sprouting-
GO:0051354IC-negative regulation of oxidoreductase activity18606987
GO:0051646IEA-mitochondrion localization-
GO:0051788IMP-response to misfolded protein14675537
GO:0060271TAS-cilium assembly-
GO:0060632IC-regulation of microtubule-based movement19228685
GO:0060765TAS-regulation of androgen receptor signaling pathway18852123
GO:0060997IEA-dendritic spine morphogenesis-
GO:0061734IGI-parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization20457763
GO:0070201IEA-regulation of establishment of protein localization-
GO:0070301IMP-cellular response to hydrogen peroxide18606987
GO:0070842IMP-aggresome assembly14675537
GO:0070845IMP-polyubiquitinated misfolded protein transport14675537
GO:0070846IMP-Hsp90 deacetylation19158084
GO:0070848IMP-response to growth factor18356165
GO:0070932IEA-histone H3 deacetylation-
GO:0071218IEA-cellular response to misfolded protein-
GO:0090035IMP-positive regulation of chaperone-mediated protein complex assembly19158084
GO:0090042IDA-tubulin deacetylation19228685
GO:0090042ISS-tubulin deacetylation-
GO:1901300IDA-positive regulation of hydrogen peroxide-mediated programmed cell death18606987
GO:1903146TAS-regulation of mitophagy25548531
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HDAC6RUNX210730812391164 Affinity Capture-Western
HDAC6RUNX211533012391164 Affinity Capture-Western
HDAC6CBFA2T311533011533236 Affinity Capture-Western
HDAC6CBFA2T310731111533236 Affinity Capture-Western
HDAC6CDKN1A10746016082198 Reconstituted Complex
HDAC6CDKN1A11533016082198 Reconstituted Complex
HDAC6CFTR10750614675537 Affinity Capture-Western
HDAC6CFTR11533014675537 Affinity Capture-Western
HDAC6CORD111533012718889 Reconstituted Complex
HDAC6CORD110771412718889 Reconstituted Complex
HDAC6CTNNB110788018356165 Biochemical Activity
HDAC6CTNNB111533018356165 Biochemical Activity
HDAC6CYLD10792019893491 Affinity Capture-Western; Reconstituted Complex
HDAC6CYLD11533019893491 Affinity Capture-Western; Reconstituted Complex
HDAC6EGFR10827620029029 20133936 Affinity Capture-Western; Co-fractionation; PCA
HDAC6EGFR11533020029029 20133936 Affinity Capture-Western; Co-fractionation; PCA
HDAC6CTTN11533017643370 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HDAC6CTTN10833217643370 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HDAC6EP30010834719344692 Affinity Capture-Western
HDAC6EP30011533019344692 Affinity Capture-Western
HDAC6ERBB210837620029029 PCA
HDAC6ERBB211533020029029 PCA
HDAC6ERBB311533020029029 PCA
HDAC6ERBB310837720029029 PCA
HDAC6ERBB411533020029029 PCA
HDAC6ERBB410837820029029 PCA
HDAC6FAT110848919033385 Affinity Capture-Western
HDAC6FAT111533019033385 Affinity Capture-Western
HDAC6FNTA11533019228685 Affinity Capture-Western; Reconstituted Complex
HDAC6FNTA10862519228685 Affinity Capture-Western; Reconstituted Complex
HDAC6FNTB10862719228685 Affinity Capture-Western; Reconstituted Complex
HDAC6FNTB11533019228685 Affinity Capture-Western; Reconstituted Complex
HDAC6HIF1A10933816951198 Affinity Capture-Western
HDAC6HIF1A11533016951198 Affinity Capture-Western
HDAC6NR4A110940719321449 Affinity Capture-MS
HDAC6NR4A111533019321449 Affinity Capture-MS
HDAC6HSP90AA110955215916966 15937340 18591380 19158084 Affinity Capture-Western
HDAC6HSP90AA111533015916966 15937340 18591380 19158084 Affinity Capture-Western
HDAC6SMAD711026715831498 15831516 Affinity Capture-Western
HDAC6SMAD711533015831498 15831516 Affinity Capture-Western
HDAC6MAPT11030818636984 Affinity Capture-Western; Reconstituted Complex
HDAC6MAPT11533018636984 Affinity Capture-Western; Reconstituted Complex
HDAC6PPA111146016186112 Affinity Capture-Western
HDAC6PPA111533016186112 Affinity Capture-Western
HDAC6PPP1CC11149514670976 Affinity Capture-Western; Co-purification; Far Western; Reconstituted Complex
HDAC6PPP1CC11533014670976 Affinity Capture-Western; Co-purification; Far Western; Reconstituted Complex
HDAC6PKN111157119036992 Affinity Capture-Western; Reconstituted Complex
HDAC6PKN111533019036992 Affinity Capture-Western; Reconstituted Complex
HDAC6RELB11190314743216 Affinity Capture-MS
HDAC6RELB11533014743216 Affinity Capture-MS
HDAC6SYK11271716288017 Affinity Capture-Western; Reconstituted Complex
HDAC6SYK11533016288017 Affinity Capture-Western; Reconstituted Complex
HDAC6TUBB2A11313112024216 Biochemical Activity
HDAC6TUBB2A11533012024216 Biochemical Activity
HDAC6UBC11316417512543 Affinity Capture-Western
HDAC6UBC11533017512543 Affinity Capture-Western
HDAC6UBE2D111316917588522 Biochemical Activity
HDAC6UBE2D111533017588522 Biochemical Activity
HDAC6UBE2D311317117588522 Biochemical Activity
HDAC6UBE2D311533017588522 Biochemical Activity
HDAC6UBE2E111317217588522 Biochemical Activity
HDAC6UBE2E111533017588522 Biochemical Activity
HDAC6UBE2H11317617588522 Biochemical Activity
HDAC6UBE2H11533017588522 Biochemical Activity
HDAC6ZBTB1611349815467736 Affinity Capture-Western; Reconstituted Complex
HDAC6ZBTB1611533015467736 Affinity Capture-Western; Reconstituted Complex
HDAC6TUBA1A11360312024216 12486003 12606581 Biochemical Activity
HDAC6TUBA1A11533012024216 12486003 12606581 Biochemical Activity
HDAC6EEA111399920133936 Co-fractionation
HDAC6EEA111533020133936 Co-fractionation
HDAC6NR0B211401215835920 Reconstituted Complex
HDAC6NR0B211533015835920 Reconstituted Complex
HDAC6DYNLL111420615937109 Affinity Capture-Western
HDAC6DYNLL111533015937109 Affinity Capture-Western
BCORHDAC612022810898795 Affinity Capture-Western
BCORHDAC611533010898795 Affinity Capture-Western
HDAC11HDAC612297011948178 Affinity Capture-Western
HDAC11HDAC611533011948178 Affinity Capture-Western
LCORHDAC612409312535528 19744931 Affinity Capture-Western; Reconstituted Complex
LCORHDAC611533012535528 19744931 Affinity Capture-Western; Reconstituted Complex
TUBB2BHDAC613148312606581 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TUBB2BHDAC611533012606581 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DIAPH3HDAC611533015976449 Affinity Capture-Western
DIAPH3HDAC612355915976449 Affinity Capture-Western
SIRT2HDAC611659317516032 Affinity Capture-Western
SIRT2HDAC611533017516032 Affinity Capture-Western
G3BP1HDAC611544818079183 Affinity Capture-Western; Reconstituted Complex
G3BP1HDAC611533018079183 Affinity Capture-Western; Reconstituted Complex
UBDHDAC611579119033385 Reconstituted Complex
UBDHDAC611533019033385 Reconstituted Complex
ACTR1AHDAC611542519737819 Affinity Capture-Western
ACTR1AHDAC611533019737819 Affinity Capture-Western
MAPRE1HDAC611658119737819 Affinity Capture-Western
MAPRE1HDAC611533019737819 Affinity Capture-Western
TARDBPHDAC611533019910924 Affinity Capture-RNA
TARDBPHDAC611700319910924 Affinity Capture-RNA
DNAJB6HDAC611536020159555 Affinity Capture-Western
DNAJB6HDAC611533020159555 Affinity Capture-Western
DNAJB8HDAC612791920159555 Affinity Capture-Western
DNAJB8HDAC611533020159555 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
HDAC6rs2075840 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:1333752
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-3232'