AutismKB 2.0

Annotation Details for PDCD6


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Basic Information Top
Gene Symbol:PDCD6 ( ALG-2,FLJ46208,MGC111017,MGC119050,MGC9123,PEF1B )
Gene Full Name: programmed cell death 6
Band: 5p15.33
Quick LinksEntrez ID:10016; OMIM: 601057; Uniprot ID:PDCD6_HUMAN; ENSEMBL ID: ENSG00000063438,ENSG00000249915; HGNC ID: 8765
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005634IDA-nucleus16957052
GO:0005737IDA-cytoplasm21122810
GO:0005768IEA-endosome-
GO:0005783IDA-endoplasmic reticulum17196169
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0030127IDA-COPII vesicle coat27716508
GO:0031410IDA-cytoplasmic vesicle21122810
GO:0031463IDAcolocalizes_withCul3-RING ubiquitin ligase complex27716508
GO:0070062IDA-extracellular exosome19056867
GO:0070971IDA-endoplasmic reticulum exit site27813252
GO:0070971IMP-endoplasmic reticulum exit site16957052
GO ID Evidence Qualifier GO_term References
GO:0000287ISS-magnesium ion binding-
GO:0004198IBA-calcium-dependent cysteine-type endopeptidase activity-
GO:0005509IDA-calcium ion binding25667979
GO:0005509ISS-calcium ion binding-
GO:0005515IPI-protein binding11883939
GO:0042802IPI-identical protein binding16189514
GO:0042803IDA-protein homodimerization activity25667979
GO:0043495IMP-protein anchor16957052
GO:0046983IPI-protein dimerization activity11883899
GO:0048306IPI-calcium-dependent protein binding16957052
GO:0060090IMP-binding, bridging19520058
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001938IDA-positive regulation of endothelial cell proliferation21893193
GO:0006508IEA-proteolysis-
GO:0006886IDA-intracellular protein transport21122810
GO:0006888IMP-ER to Golgi vesicle-mediated transport27716508
GO:0006919IEA-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0010595IDA-positive regulation of endothelial cell migration21893193
GO:0014029IMP-neural crest formation27716508
GO:0014032IMP-neural crest cell development27716508
GO:0030948IDA-negative regulation of vascular endothelial growth factor receptor signaling pathway21893193
GO:0032007IDA-negative regulation of TOR signaling21893193
GO:0034605IDA-cellular response to heat21122810
GO:0036324IDA-vascular endothelial growth factor receptor-2 signaling pathway21893193
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process16132846
GO:0045766IDA-positive regulation of angiogenesis21893193
GO:0048208IMP-COPII vesicle coating27716508
GO:0051592ISS-response to calcium ion-
GO:0051898IDA-negative regulation of protein kinase B signaling21893193
GO:0097190TAS-apoptotic signaling pathway8560270
GO:1902527IMP-positive regulation of protein monoubiquitination27716508
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PDCD6ANXA1111533311883939 Far Western; Reconstituted Complex; Two-hybrid
PDCD6ANXA1110680811883939 Far Western; Reconstituted Complex; Two-hybrid
PDCD6FAS10685111606059 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PDCD6FAS11533311606059 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PDCD6MAP3K511038112372597 Affinity Capture-Western; Co-localization; Reconstituted Complex
PDCD6MAP3K511533312372597 Affinity Capture-Western; Co-localization; Reconstituted Complex
PDCD6PDCD6IP1153329880530 11883939 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PDCD6PDCD6IP1153339880530 11883939 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SH3KBP1PDCD611902910858458 Reconstituted Complex
SH3KBP1PDCD611533310858458 Reconstituted Complex
PEF1PDCD611533311278427 Affinity Capture-Western; Co-fractionation
PEF1PDCD613927511278427 Affinity Capture-Western; Co-fractionation
PDCD6PDCD611533316189514 Two-hybrid
HEBP2PDCD611533316189514 Two-hybrid
HEBP2PDCD611712816189514 Two-hybrid
MAPK1IP1LPDCD611533316189514 Two-hybrid
MAPK1IP1LPDCD612503016189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109283
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1307'