AutismKB 2.0

Annotation Details for BCL2L11


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BCL2L11 ( BAM,BIM,BIM-alpha6,BIM-beta6,BIM-beta7,BOD,BimEL,BimL )
Gene Full Name: BCL2-like 11 (apoptosis facilitator)
Band: 2q13
Quick LinksEntrez ID:10018; OMIM: 603827; Uniprot ID:B2L11_HUMAN; ENSEMBL ID: ENSG00000153094; HGNC ID: 994
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IBA-mitochondrion-
GO:0005741TAS-mitochondrial outer membrane-
GO:0005829TAS-cytosol-
GO:0005868IEA-cytoplasmic dynein complex-
GO:0012505IEA-endomembrane system-
GO:0019898IEA-extrinsic component of membrane-
GO:0097136IEA-Bcl-2 family protein complex-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding14596824
GO:0008017IBA-microtubule binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0070840IEA-dynein complex binding-
GO ID Evidence Qualifier GO_term References
GO:0001701IEA-in utero embryonic development-
GO:0001782IEA-B cell homeostasis-
GO:0001783IEA-B cell apoptotic process-
GO:0001822IEA-kidney development-
GO:0001844TAS-protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
GO:0002262IEA-myeloid cell homeostasis-
GO:0006915TAS-apoptotic process10381623
GO:0007127IBANOTmeiosis I-
GO:0007160IEA-cell-matrix adhesion-
GO:0007283IEA-spermatogenesis-
GO:0007420IEA-brain development-
GO:0008584IEA-male gonad development-
GO:0008630IDA-intrinsic apoptotic signaling pathway in response to DNA damage11546872
GO:0030879IEA-mammary gland development-
GO:0032464IDA-positive regulation of protein homooligomerization21041309
GO:0034976IDA-response to endoplasmic reticulum stress22761832
GO:0035148IEA-tube formation-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0043029IEA-T cell homeostasis-
GO:0043065IMP-positive regulation of apoptotic process17289999
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043280IEA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043525IEA-positive regulation of neuron apoptotic process-
GO:0043583IEA-ear development-
GO:0045787IEA-positive regulation of cell cycle-
GO:0046620IEA-regulation of organ growth-
GO:0048066IEA-developmental pigmentation-
GO:0048070IEA-regulation of developmental pigmentation-
GO:0048536IEA-spleen development-
GO:0048538IEA-thymus development-
GO:0048563IEA-post-embryonic animal organ morphogenesis-
GO:0060139IEA-positive regulation of apoptotic process by virus-
GO:0060154IEA-cellular process regulating host cell cycle in response to virus-
GO:0070242IEA-thymocyte apoptotic process-
GO:0090200IGI-positive regulation of release of cytochrome c from mitochondria21041309
GO:0090200IMP-positive regulation of release of cytochrome c from mitochondria17289999
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
GO:1900740TAS-positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-
GO:1902237TAS-positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway22013210
GO:1902263IEA-apoptotic process involved in embryonic digit morphogenesis-
GO:1903896TAS-positive regulation of IRE1-mediated unfolded protein response22013210
GO:2000271IDA-positive regulation of fibroblast apoptotic process11997495
GO:2001244TAS-positive regulation of intrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BCL2L11BCL21070689430630 9731710 15694340 19805519 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL2L11BCL21153359430630 9731710 15694340 19805519 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL2L11BCL2A11070699731710 Two-hybrid
BCL2L11BCL2A11153359731710 Two-hybrid
BCL2L11BCL2L11070709430630 9731710 14596824 15694340 Affinity Capture-Western; FRET; Two-hybrid
BCL2L11BCL2L11153359430630 9731710 14596824 15694340 Affinity Capture-Western; FRET; Two-hybrid
BCL2L11BCL2L21153359430630 9731710 Affinity Capture-Western; Two-hybrid
BCL2L11BCL2L21070719430630 9731710 Affinity Capture-Western; Two-hybrid
BCL2L11BTK10716015096481 Reconstituted Complex
BCL2L11BTK11533515096481 Reconstituted Complex
BCL2L11GTF2I10922415096481 Reconstituted Complex
BCL2L11GTF2I11533515096481 Reconstituted Complex
BCL2L11MCL11103389731710 10837489 15694340 Affinity Capture-Western; Two-hybrid
BCL2L11MCL11153359731710 10837489 15694340 Affinity Capture-Western; Two-hybrid
BCL2L11SMARCB111533515096481 Reconstituted Complex
BCL2L11SMARCB111248215096481 Reconstituted Complex
BCL2L11UBC11316415486195 Affinity Capture-Western
BCL2L11UBC11533515486195 Affinity Capture-Western
BCL2L11VDAC111325912118373 Affinity Capture-Western
BCL2L11VDAC111533512118373 Affinity Capture-Western
BCL2L11DYNLL111420614561217 15193260 Reconstituted Complex
BCL2L11DYNLL111533514561217 15193260 Reconstituted Complex
DYNLL2BCL2L1112668014561217 Reconstituted Complex
DYNLL2BCL2L1111533514561217 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
BCL2L11rs6746608, rs724710 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1197519
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081008-1'