Gene Symbol:	HCN4 ( SSS2 )
Gene Full Name:	hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Band:	15q24.1
Quick Links	Entrez ID:10021; OMIM: 605206; Uniprot ID:HCN4_HUMAN; ENSEMBL ID: ENSG00000138622; HGNC ID: 16882
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005886	IDA	-	plasma membrane	12750403
GO:0005886	TAS	-	plasma membrane	-
GO:0031226	IDA	-	intrinsic component of plasma membrane	16407510
GO:0048471	IDA	-	perinuclear region of cytoplasm	12750403
GO:0098855	IDA	-	HCN channel complex	10228147

GO ID	Evidence	Qualifier	GO_term	References
GO:0005222	IDA	-	intracellular cAMP activated cation channel activity	10228147
GO:0005248	IMP	-	voltage-gated sodium channel activity	22748890
GO:0005249	IDA	-	voltage-gated potassium channel activity	16407510
GO:0005249	IMP	-	voltage-gated potassium channel activity	22748890
GO:0030552	IEA	-	cAMP binding	-
GO:0042802	IPI	-	identical protein binding	22006928
GO:0086041	IMP	-	voltage-gated potassium channel activity involved in SA node cell action potential depolarization	16407510

GO ID	Evidence	Qualifier	GO_term	References
GO:0002027	IMP	-	regulation of heart rate	16407510
GO:0003254	IDA	-	regulation of membrane depolarization	12750403
GO:0006812	IDA	-	cation transport	12750403
GO:0006936	TAS	-	muscle contraction	10228147
GO:0008015	NAS	-	blood circulation	10228147
GO:0034765	IEA	-	regulation of ion transmembrane transport	-
GO:0035725	IMP	-	sodium ion transmembrane transport	22748890
GO:0042391	IMP	-	regulation of membrane potential	22748890
GO:0055117	IMP	-	regulation of cardiac muscle contraction	12750403
GO:0060078	IEA	-	regulation of postsynaptic membrane potential	-
GO:0071320	IDA	-	cellular response to cAMP	12750403
GO:0071321	IDA	-	cellular response to cGMP	22748890
GO:0071805	IDA	-	potassium ion transmembrane transport	16407510
GO:0071805	IMP	-	potassium ion transmembrane transport	22748890
GO:0086012	IC	-	membrane depolarization during cardiac muscle cell action potential	10228147
GO:0086015	IMP	-	SA node cell action potential	12750403
GO:0086046	IMP	-	membrane depolarization during SA node cell action potential	16407510
GO:0086091	IMP	-	regulation of heart rate by cardiac conduction	12750403
GO:0098719	IDA	-	sodium ion import across plasma membrane	10228147
GO:0098909	IMP	-	regulation of cardiac muscle cell action potential involved in regulation of contraction	16407510
GO:1990573	IDA	-	potassium ion import across plasma membrane	10228147

Gene Symbol	Interactant	Interaction ID	References	Description
HCN4	HCN2	107081	12928435	Affinity Capture-Western
HCN4	HCN2	115338	12928435	Affinity Capture-Western
HCN1	HCN4	131543	12928435	Affinity Capture-Western
HCN1	HCN4	115338	12928435	Affinity Capture-Western
HCN3	HCN4	121691	12928435	Affinity Capture-Western
HCN3	HCN4	115338	12928435	Affinity Capture-Western

AutismKB 2.0

Annotation Details for HCN4