AutismKB 2.0

Annotation Details for HCN4


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Basic Information Top
Gene Symbol:HCN4 ( SSS2 )
Gene Full Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Band: 15q24.1
Quick LinksEntrez ID:10021; OMIM: 605206; Uniprot ID:HCN4_HUMAN; ENSEMBL ID: ENSG00000138622; HGNC ID: 16882
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane12750403
GO:0005886TAS-plasma membrane-
GO:0031226IDA-intrinsic component of plasma membrane16407510
GO:0048471IDA-perinuclear region of cytoplasm12750403
GO:0098855IDA-HCN channel complex10228147
GO ID Evidence Qualifier GO_term References
GO:0005222IDA-intracellular cAMP activated cation channel activity10228147
GO:0005248IMP-voltage-gated sodium channel activity22748890
GO:0005249IDA-voltage-gated potassium channel activity16407510
GO:0005249IMP-voltage-gated potassium channel activity22748890
GO:0030552IEA-cAMP binding-
GO:0042802IPI-identical protein binding22006928
GO:0086041IMP-voltage-gated potassium channel activity involved in SA node cell action potential depolarization16407510
GO ID Evidence Qualifier GO_term References
GO:0002027IMP-regulation of heart rate16407510
GO:0003254IDA-regulation of membrane depolarization12750403
GO:0006812IDA-cation transport12750403
GO:0006936TAS-muscle contraction10228147
GO:0008015NAS-blood circulation10228147
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0035725IMP-sodium ion transmembrane transport22748890
GO:0042391IMP-regulation of membrane potential22748890
GO:0055117IMP-regulation of cardiac muscle contraction12750403
GO:0060078IEA-regulation of postsynaptic membrane potential-
GO:0071320IDA-cellular response to cAMP12750403
GO:0071321IDA-cellular response to cGMP22748890
GO:0071805IDA-potassium ion transmembrane transport16407510
GO:0071805IMP-potassium ion transmembrane transport22748890
GO:0086012IC-membrane depolarization during cardiac muscle cell action potential10228147
GO:0086015IMP-SA node cell action potential12750403
GO:0086046IMP-membrane depolarization during SA node cell action potential16407510
GO:0086091IMP-regulation of heart rate by cardiac conduction12750403
GO:0098719IDA-sodium ion import across plasma membrane10228147
GO:0098909IMP-regulation of cardiac muscle cell action potential involved in regulation of contraction16407510
GO:1990573IDA-potassium ion import across plasma membrane10228147
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HCN4HCN210708112928435 Affinity Capture-Western
HCN4HCN211533812928435 Affinity Capture-Western
HCN1HCN413154312928435 Affinity Capture-Western
HCN1HCN411533812928435 Affinity Capture-Western
HCN3HCN412169112928435 Affinity Capture-Western
HCN3HCN411533812928435 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1298209
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050420-360'