AutismKB 2.0

Annotation Details for DNM1L


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Basic Information Top
Gene Symbol:DNM1L ( DLP1,DRP1,DVLP,DYMPLE,DYNIV-11,FLJ41912,HDYNIV,VPS1 )
Gene Full Name: dynamin 1-like
Band: 12p11.21
Quick LinksEntrez ID:10059; OMIM: 603850; Uniprot ID:DNM1L_HUMAN; ENSEMBL ID: ENSG00000087470; HGNC ID: 2973
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005737IDA-cytoplasm12618434
GO:0005739IDA-mitochondrion11514614
GO:0005741IDA-mitochondrial outer membrane21149567
GO:0005741TAS-mitochondrial outer membrane-
GO:0005777IDA-peroxisome12618434
GO:0005777IMP-peroxisome23921378
GO:0005783IDA-endoplasmic reticulum9472031
GO:0005783IDANOTendoplasmic reticulum11514614
GO:0005789TAS-endoplasmic reticulum membrane25767741
GO:0005794IDA-Golgi apparatus20688057
GO:0005829IDA-cytosol22265414
GO:0005829IMP-cytosol11514614
GO:0005829TAS-cytosol-
GO:0005874IDAcolocalizes_withmicrotubule9472031
GO:0005903IEA-brush border-
GO:0005905IEA-clathrin-coated pit-
GO:0016020IDA-membrane19946888
GO:0030054IEA-cell junction-
GO:0030672IEA-synaptic vesicle membrane-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0043234IDA-protein complex17408615
GO:0048471IDA-perinuclear region of cytoplasm9472031
GO:0099073IDAcolocalizes_withmitochondrion-derived vesicle26618722
GO ID Evidence Qualifier GO_term References
GO:0003924IDA-GTPase activity22265414
GO:0005096IC-GTPase activator activity25767741
GO:0005515IPI-protein binding9731200
GO:0005525IEA-GTP binding-
GO:0008017IBA-microtubule binding-
GO:0008289IEA-lipid binding-
GO:0017137IDA-Rab GTPase binding25767741
GO:0030276IEA-clathrin binding-
GO:0030742IDA-GTP-dependent protein binding25767741
GO:0031625IPI-ubiquitin protein ligase binding16874301
GO:0042803IDA-protein homodimerization activity22265414
GO:0051433IEA-BH2 domain binding-
GO ID Evidence Qualifier GO_term References
GO:0000266IDA-mitochondrial fission23530241
GO:0000266IMP-mitochondrial fission23349293
GO:0001836IMP-release of cytochrome c from mitochondria20850011
GO:0003374IDA-dynamin family protein polymerization involved in mitochondrial fission11514614
GO:0006897IEA-endocytosis-
GO:0007005IMP-mitochondrion organization11514614
GO:0007029IMPNOTendoplasmic reticulum organization11514614
GO:0010637IEA-negative regulation of mitochondrial fusion-
GO:0010821IMP-regulation of mitochondrion organization18353969
GO:0016559IDA-peroxisome fission12618434
GO:0016559IMP-peroxisome fission18353969
GO:0032459IDA-regulation of protein oligomerization20850011
GO:0036466IEA-synaptic vesicle recycling via endosome-
GO:0043065IMP-positive regulation of apoptotic process20850011
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043653IMP-mitochondrial fragmentation involved in apoptotic process12499352
GO:0048312IMP-intracellular distribution of mitochondria11514614
GO:0050714IDA-positive regulation of protein secretion9570752
GO:0051259IMP-protein oligomerization27145208
GO:0051289IDA-protein homotetramerization18353969
GO:0060047IEA-heart contraction-
GO:0061003IEA-positive regulation of dendritic spine morphogenesis-
GO:0061025IDA-membrane fusion20850011
GO:0070266IMP-necroptotic process22265414
GO:0070584IMP-mitochondrion morphogenesis21149567
GO:0070585IEA-protein localization to mitochondrion-
GO:0090141IMP-positive regulation of mitochondrial fission19279012
GO:0090141TAS-positive regulation of mitochondrial fission20436456
GO:0090149IDA-mitochondrial membrane fission11514614
GO:0090200IMP-positive regulation of release of cytochrome c from mitochondria21149567
GO:0090650IEA-cellular response to oxygen-glucose deprivation-
GO:0097194TAS-execution phase of apoptosis-
GO:1900063IMP-regulation of peroxisome organization18353969
GO:1900244IEA-positive regulation of synaptic vesicle endocytosis-
GO:1903146IGI-regulation of mitophagy19279012
GO:1903578IEA-regulation of ATP metabolic process-
GO:1904579IEA-cellular response to thapsigargin-
GO:1905395IEA-response to flavonoid-
GO:1990910IEA-response to hypobaric hypoxia-
GO:2000302IEA-positive regulation of synaptic vesicle exocytosis-
GO:2001244IMP-positive regulation of intrinsic apoptotic signaling pathway20850011
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DNM1LGSK3B1153709731200 Reconstituted Complex; Two-hybrid
DNM1LGSK3B1091879731200 Reconstituted Complex; Two-hybrid
DNM1LUBC11537016936636 Affinity Capture-Western
DNM1LUBC11316416936636 Affinity Capture-Western
DNM1LPEX11B11537020826455 Phenotypic Enhancement
DNM1LPEX11B11432720826455 Phenotypic Enhancement
DNM1LPEX11A11537020826455 Phenotypic Enhancement
DNM1LPEX11A11432820826455 Phenotypic Enhancement
FIS1DNM1L11537012861026 Affinity Capture-Western; Reconstituted Complex
FIS1DNM1L11923012861026 Affinity Capture-Western; Reconstituted Complex
RGAG4DNM1L11537016936636 Affinity Capture-Western
RGAG4DNM1L13106516936636 Affinity Capture-Western
PEX11GDNM1L11537020826455 Phenotypic Enhancement
PEX11GDNM1L12499020826455 Phenotypic Enhancement
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1921256
  • Data Attributes: MGI curated and HomoloGene calculated
No data