AutismKB 2.0

Annotation Details for NR1H3


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Basic Information Top
Gene Symbol:NR1H3 ( LXR-a,LXRA,RLD-1 )
Gene Full Name: nuclear receptor subfamily 1, group H, member 3
Band: 11p11.2
Quick LinksEntrez ID:10062; OMIM: 602423; Uniprot ID:NR1H3_HUMAN; ENSEMBL ID: ENSG00000025434; HGNC ID: 7966
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin18511497
GO:0005634IDA-nucleus25661920
GO:0005654TAS-nucleoplasm-
GO:0043235IDA-receptor complex18511497
GO:0090575IDA-RNA polymerase II transcription factor complex18511497
GO ID Evidence Qualifier GO_term References
GO:0003677TAS-DNA binding7744246
GO:0003707IEA-steroid hormone receptor activity-
GO:0003713TAS-transcription coactivator activity7744246
GO:0004879TAS-RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding7744246
GO:0005515IPI-protein binding12040021
GO:0008270IEA-zinc ion binding-
GO:0015485TAS-cholesterol binding11090131
GO:0032810IDA-sterol response element binding19628791
GO:0043565IEA-sequence-specific DNA binding-
GO:0044212IDA-transcription regulatory region DNA binding19229075
GO:0044212IDAcontributes_totranscription regulatory region DNA binding18511497
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0010745IC-negative regulation of macrophage derived foam cell differentiation17693624
GO:0010867IMP-positive regulation of triglyceride biosynthetic process17693624
GO:0010870IDA-positive regulation of receptor biosynthetic process18511497
GO:0010875IDA-positive regulation of cholesterol efflux16141411
GO:0010875IMP-positive regulation of cholesterol efflux17186944
GO:0010887IMP-negative regulation of cholesterol storage17693624
GO:0030522IEA-intracellular receptor signaling pathway-
GO:0032270IMP-positive regulation of cellular protein metabolic process17186944
GO:0032369IMP-negative regulation of lipid transport17693624
GO:0032376IDA-positive regulation of cholesterol transport16141411
GO:0032570IDA-response to progesterone16141411
GO:0034145IDA-positive regulation of toll-like receptor 4 signaling pathway18511497
GO:0042632ISS-cholesterol homeostasis-
GO:0042752TAS-regulation of circadian rhythm18511497
GO:0043031ISS-negative regulation of macrophage activation-
GO:0043277IMP-apoptotic cell clearance19628791
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0045723IMP-positive regulation of fatty acid biosynthetic process17186944
GO:0045893IDA-positive regulation of transcription, DNA-templated25661920
GO:0045893IMP-positive regulation of transcription, DNA-templated19628791
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16141411
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter17186944
GO:0048550IMP-negative regulation of pinocytosis17693624
GO:0050728ISS-negative regulation of inflammatory response-
GO:0051006IMP-positive regulation of lipoprotein lipase activity17186944
GO:0055088ISS-lipid homeostasis-
GO:0055092ISS-sterol homeostasis-
GO:0060336NAS-negative regulation of interferon-gamma-mediated signaling pathway21268089
GO:0070328ISS-triglyceride homeostasis-
GO:0071222IDA-cellular response to lipopolysaccharide18511497
GO:0090188ISS-negative regulation of pancreatic juice secretion-
GO:0090341ISS-negative regulation of secretion of lysosomal enzymes-
GO:2000188ISS-regulation of cholesterol homeostasis-
GO:2000189IDA-positive regulation of cholesterol homeostasis18511497
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NR1H3BARD110705619164445 Affinity Capture-Western
NR1H3BARD111537319164445 Affinity Capture-Western
NR1H3PPARA1153738621574 Reconstituted Complex
NR1H3PPARA1114618621574 Reconstituted Complex
NR1H3RXRA1153738621574 Reconstituted Complex
NR1H3RXRA1121688621574 Reconstituted Complex
NR1H3UBC11537317936707 Affinity Capture-Western
NR1H3UBC11316417936707 Affinity Capture-Western
NR1H3LZTR111537320211142 Two-hybrid
NR1H3LZTR111385220211142 Two-hybrid
NR1H3NR0B211537312198243 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR1H3NR0B211401212198243 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR1H3EDF111426012040021 Reconstituted Complex; Two-hybrid
NR1H3EDF111537312040021 Reconstituted Complex; Two-hybrid
NR1H3NCOR111497312663743 Two-hybrid
NR1H3NCOR111537312663743 Two-hybrid
SIRT1NR1H311698317936707 Affinity Capture-Western
SIRT1NR1H311537317936707 Affinity Capture-Western
SS18L1NR1H311750520211142 Two-hybrid
SS18L1NR1H311537320211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1352462
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050410-7'