AutismKB 2.0

Annotation Details for HUWE1


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Basic Information Top
Gene Symbol:HUWE1 ( ARF-BP1,HECTH9,HSPC272,Ib772,KIAA0312,LASU1,MULE,UREB1 )
Gene Full Name: HECT, UBA and WWE domain containing 1
Band: Xp11.22
Quick LinksEntrez ID:10075; OMIM: 300697; Uniprot ID:HUWE1_HUMAN; ENSEMBL ID: ENSG00000086758; HGNC ID: 30892
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634ISS-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm19713937
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO:0034774TAS-secretory granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0003677ISS-DNA binding-
GO:0003723IDA-RNA binding22658674
GO:0004842EXP-ubiquitin-protein transferase activity19028597
GO:0004842IDA-ubiquitin-protein transferase activity15989957
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding15989956
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination15989957
GO:0000209TAS-protein polyubiquitination-
GO:0006284IMP-base-excision repair19713937
GO:0006513IDA-protein monoubiquitination19713937
GO:0016574IDA-histone ubiquitination15767685
GO:0030154IEA-cell differentiation-
GO:0043312TAS-neutrophil degranulation-
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24270810
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HUWE1ATM11538517478428 Affinity Capture-Western
HUWE1ATM10696217478428 Affinity Capture-Western
HUWE1CDC610742617567951 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HUWE1CDC611538517567951 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HUWE1MCL111538516213503 Affinity Capture-Western; Biochemical Activity
HUWE1MCL111033816213503 Affinity Capture-Western; Biochemical Activity
HUWE1MYC11069416269333 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HUWE1MYC11538516269333 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
HUWE1USP711538519615732 Affinity Capture-MS
HUWE1USP711362219615732 Affinity Capture-MS
HUWE1UBL4A11538519615732 Affinity Capture-MS
HUWE1UBL4A11388519615732 Affinity Capture-MS
HUWE1PIAS211452316269333 Affinity Capture-Western; Reconstituted Complex
HUWE1PIAS211538516269333 Affinity Capture-Western; Reconstituted Complex
SLX1BHUWE112247919596235 Affinity Capture-MS
SLX1BHUWE111538519596235 Affinity Capture-MS
USP49HUWE111538519615732 Affinity Capture-MS
USP49HUWE111738219615732 Affinity Capture-MS
USP50HUWE113188419615732 Affinity Capture-MS
USP50HUWE111538519615732 Affinity Capture-MS
VCPIP1HUWE111538519615732 Affinity Capture-MS
VCPIP1HUWE112312519615732 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
HUWE1MCL131536815989957 Mule interacts with and ubiquitinates Mcl-1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1926884
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081104-387'