AutismKB 2.0

Annotation Details for RASGRP1


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Basic Information Top
Gene Symbol:RASGRP1 ( CALDAG-GEFI,CALDAG-GEFII,MGC129998,MGC129999,RASGRP,V,hRasGRP1 )
Gene Full Name: RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Band: 15q14
Quick LinksEntrez ID:10125; OMIM: 603962; Uniprot ID:GRP1_HUMAN; ENSEMBL ID: ENSG00000172575; HGNC ID: 9878
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005794IDA-Golgi apparatus21968647
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0016020TAS-membrane9582122
GO:0042629IEA-mast cell granule-
GO ID Evidence Qualifier GO_term References
GO:0001786IMP-phosphatidylserine binding23908768
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005088IMP-Ras guanyl-nucleotide exchange factor activity23908768
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005509IMP-calcium ion binding23908768
GO:0008270IMP-zinc ion binding23908768
GO:0008289TAS-lipid binding9582122
GO:0019992IMP-diacylglycerol binding23908768
GO:0031210IMP-phosphatidylcholine binding23908768
GO:0042803IMP-protein homodimerization activity23908768
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001816IEA-cytokine production-
GO:0001934IDA-positive regulation of protein phosphorylation21968647
GO:0001934IMP-positive regulation of protein phosphorylation23908768
GO:0002437IEA-inflammatory response to antigenic stimulus-
GO:0007165TAS-signal transduction9789079
GO:0007265IEA-Ras protein signal transduction-
GO:0014066IEA-regulation of phosphatidylinositol 3-kinase signaling-
GO:0030154IEA-cell differentiation-
GO:0032252IEA-secretory granule localization-
GO:0032725IMP-positive regulation of granulocyte macrophage colony-stimulating factor production19933860
GO:0032760IMP-positive regulation of tumor necrosis factor production19933860
GO:0032825IEA-positive regulation of natural killer cell differentiation-
GO:0033089IEA-positive regulation of T cell differentiation in thymus-
GO:0043303IEA-mast cell degranulation-
GO:0043406IMP-positive regulation of MAP kinase activity15899849
GO:0043547IMP-positive regulation of GTPase activity23908768
GO:0045954IMP-positive regulation of natural killer cell mediated cytotoxicity19933860
GO:0046330IMP-positive regulation of JNK cascade19933860
GO:0046579IMP-positive regulation of Ras protein signal transduction19933860
GO:0047496IEA-vesicle transport along microtubule-
GO:0051259IMP-protein oligomerization23908768
GO:0070372IMP-regulation of ERK1 and ERK2 cascade23908768
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade19933860
GO:0090630IDA-activation of GTPase activity10807788
GO:0090630IMP-activation of GTPase activity12845332
GO:1900274IMPNOTregulation of phospholipase C activity19933860
GO:1900744IMPNOTregulation of p38MAPK cascade19933860
GO:1902715IMP-positive regulation of interferon-gamma secretion19933860
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RASGRP1PPM1B11149017353931 Affinity Capture-MS
RASGRP1PPM1B11542917353931 Affinity Capture-MS
RASGRP1VHL11326917353931 Affinity Capture-MS
RASGRP1VHL11542917353931 Affinity Capture-MS
RASGRP1DGKZ11409511257115 Affinity Capture-Western
RASGRP1DGKZ11542911257115 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1314635
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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