AutismKB 2.0

Annotation Details for ABI2


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Basic Information Top
Gene Symbol:ABI2 ( ABI-2,ABI2B,AIP-1,AblBP3,SSH3BP2,argBPIA,argBPIB )
Gene Full Name: abl-interactor 2
Band: 2q33.2
Quick LinksEntrez ID:10152; OMIM: 606442; Uniprot ID:ABI2_HUMAN; ENSEMBL ID: ENSG00000138443; HGNC ID: 24011
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737TAS-cytoplasm8649853
GO:0005829IDA-cytosol17101133
GO:0005856IEA-cytoskeleton-
GO:0030027IDA-lamellipodium11516653
GO:0030175IDA-filopodium11516653
GO:0031209IDA-SCAR complex21107423
GO ID Evidence Qualifier GO_term References
GO:0003677TAS-DNA binding7590236
GO:0005515IPI-protein binding16189514
GO:0008093TAS-cytoskeletal adaptor activity12011975
GO:0017124IPI-SH3 domain binding7590236
GO:0017124TAS-SH3 domain binding8649853
GO:0019900NAS-kinase binding8649853
GO:0030296IEA-protein tyrosine kinase activator activity-
GO:0031625IPI-ubiquitin protein ligase binding18632609
GO:0032403IDA-protein complex binding21107423
GO:0048365IDAcontributes_toRac GTPase binding21107423
GO:0070064IPI-proline-rich region binding7590236
GO ID Evidence Qualifier GO_term References
GO:0006928IDA-movement of cell or subcellular component11516653
GO:0007010TAS-cytoskeleton organization12011975
GO:0008154NAS-actin polymerization or depolymerization11516653
GO:0016032IEA-viral process-
GO:0016477TAS-cell migration12011975
GO:0016601IDA-Rac protein signal transduction21107423
GO:0018108IDA-peptidyl-tyrosine phosphorylation17101133
GO:0061098IEA-positive regulation of protein tyrosine kinase activity-
GO:2000601IDA-positive regulation of Arp2/3 complex-mediated actin nucleation21107423
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ABI2ABL11154547590236 12569093 Affinity Capture-Western; Reconstituted Complex
ABI2ABL11065437590236 12569093 Affinity Capture-Western; Reconstituted Complex
ABI2KRT1511545416189514 Two-hybrid
ABI2KRT1511006416189514 Two-hybrid
ABI2KRT1911007816189514 Two-hybrid
ABI2KRT1911545416189514 Two-hybrid
ABI2PCM111113916189514 Two-hybrid
ABI2PCM111545416189514 Two-hybrid
ABI2UBC11316418632609 Affinity Capture-Western
ABI2UBC11545418632609 Affinity Capture-Western
ABI2VCL11325716189514 Two-hybrid
ABI2VCL11545416189514 Two-hybrid
ABI2NCK211402016189514 Two-hybrid
ABI2NCK211545416189514 Two-hybrid
ABI2ADAM1911545412463424 Reconstituted Complex; Two-hybrid
ABI2ADAM1911426712463424 Reconstituted Complex; Two-hybrid
ABI2SNAP2311545416189514 Two-hybrid
ABI2SNAP2311430316189514 Two-hybrid
SH3KBP1ABI211902910858458 Reconstituted Complex
SH3KBP1ABI211545410858458 Reconstituted Complex
CCDC53ABI211545416189514 Two-hybrid
CCDC53ABI211922516189514 Two-hybrid
KRT20ABI211545416189514 Two-hybrid
KRT20ABI211997916189514 Two-hybrid
IFT20ABI211545416189514 Two-hybrid
IFT20ABI212471116189514 Two-hybrid
TRIM32ABI211545418632609 Affinity Capture-Western; Reconstituted Complex
TRIM32ABI211660818632609 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
ABI2ADAM1929515512463424 ADAM19 interacts with ArgBP1. This interaction was modelled on a demonstrated interaction between mouse ADAM19 and human ArgBP1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:106913
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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