AutismKB 2.0

Annotation Details for TNK2


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Basic Information Top
Gene Symbol:TNK2 ( ACK,ACK1,FLJ44758,FLJ45547,p21cdc42Hs )
Gene Full Name: tyrosine kinase, non-receptor, 2
Band: 3q29
Quick LinksEntrez ID:10188; OMIM: 606994; Uniprot ID:ACK1_HUMAN; ENSEMBL ID: ENSG00000061938; HGNC ID: 19297
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus20333297
GO:0005737IDA-cytoplasm20979614
GO:0005768ISS-endosome-
GO:0005886IDA-plasma membrane20333297
GO:0005905IDA-clathrin-coated pit21169560
GO:0005912IEA-adherens junction-
GO:0016020IDA-membrane19946888
GO:0030136IDA-clathrin-coated vesicle18262180
GO:0030659IEA-cytoplasmic vesicle membrane-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0070436IDA-Grb2-EGFR complex20086093
GO ID Evidence Qualifier GO_term References
GO:0004674IEA-protein serine/threonine kinase activity-
GO:0004712IDA-protein serine/threonine/tyrosine kinase activity16257963
GO:0004713IDA-protein tyrosine kinase activity18993068
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0005095TAS-GTPase inhibitor activity8497321
GO:0005154IDA-epidermal growth factor receptor binding20086093
GO:0005515IPI-protein binding10360579
GO:0005524IEA-ATP binding-
GO:0031625IPI-ubiquitin protein ligase binding23686771
GO:0042802IPI-identical protein binding16472662
GO:0046872IEA-metal ion binding-
GO:0050699ISS-WW domain binding-
GO ID Evidence Qualifier GO_term References
GO:0006897IEA-endocytosis-
GO:0007166TAS-cell surface receptor signaling pathway20432460
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007264TAS-small GTPase mediated signal transduction8497321
GO:0016310IDA-phosphorylation20333297
GO:0016477IBA-cell migration-
GO:0030154IBA-cell differentiation-
GO:0034260IEA-negative regulation of GTPase activity-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0042127IBA-regulation of cell proliferation-
GO:0045087IBA-innate immune response-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation10587647
GO:2000369IDA-regulation of clathrin-dependent endocytosis18262180
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNK2CDC4211548511394904 20936779 Affinity Capture-Western; Two-hybrid
TNK2CDC4210743311394904 20936779 Affinity Capture-Western; Two-hybrid
TNK2CLTC10762311278436 Reconstituted Complex
TNK2CLTC11548511278436 Reconstituted Complex
TNK2FYN11548511087735 Affinity Capture-Western; Reconstituted Complex
TNK2FYN10881011087735 Affinity Capture-Western; Reconstituted Complex
TNK2GRB21091428647288 11394904 20936779 Affinity Capture-Western; Two-hybrid
TNK2GRB21154858647288 11394904 20936779 Affinity Capture-Western; Two-hybrid
TNK2MCF211548510652228 Affinity Capture-Western
TNK2MCF211033610652228 Affinity Capture-Western
HSH2DTNK211548511700021 Affinity Capture-Western; Biochemical Activity; Two-hybrid
HSH2DTNK212437511700021 Affinity Capture-Western; Biochemical Activity; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1858308
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7427'