AutismKB 2.0

Annotation Details for ADAM10


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Basic Information Top
Gene Symbol:ADAM10 ( AD10,CD156c,HsT18717,MADM,kuz )
Gene Full Name: ADAM metallopeptidase domain 10
Band: 15q21.3
Quick LinksEntrez ID:102; OMIM: 602192; Uniprot ID:ADA10_HUMAN; ENSEMBL ID: ENSG00000137845; HGNC ID: 188
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005615IEA-extracellular space-
GO:0005634ISS-nucleus-
GO:0005737ISS-cytoplasm-
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005794IDA-Golgi apparatus12475894
GO:0005798IDA-Golgi-associated vesicle12475894
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0009986IDA-cell surface12475894
GO:0014069IEA-postsynaptic density-
GO:0016020IDA-membrane19946888
GO:0016021NAS-integral component of membrane8694785
GO:0035579TAS-specific granule membrane-
GO:0070062IDA-extracellular exosome20458337
GO:0070821TAS-tertiary granule membrane-
GO:0097038IDA-perinuclear endoplasmic reticulum23091066
GO:0097197IDA-tetraspanin-enriched microdomain23035126
GO ID Evidence Qualifier GO_term References
GO:0004175ISS-endopeptidase activity-
GO:0004222IMP-metalloendopeptidase activity19114711
GO:0004222NAS-metalloendopeptidase activity8694785
GO:0004222TAS-metalloendopeptidase activity-
GO:0005102NAS-receptor binding12176995
GO:0005178NAS-integrin binding8694785
GO:0005515IPI-protein binding10527948
GO:0008237IDA-metallopeptidase activity12475894
GO:0008237IMP-metallopeptidase activity12535668
GO:0008237TAS-metallopeptidase activity-
GO:0017124IEA-SH3 domain binding-
GO:0019901ISS-protein kinase binding-
GO:0042803ISS-protein homodimerization activity-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001701ISS-in utero embryonic development-
GO:0006468ISS-protein phosphorylation-
GO:0006509IDA-membrane protein ectodomain proteolysis12714508
GO:0006509IMP-membrane protein ectodomain proteolysis17965014
GO:0007162IDA-negative regulation of cell adhesion12714508
GO:0007162NAS-negative regulation of cell adhesion8694785
GO:0007219ISS-Notch signaling pathway-
GO:0007219TAS-Notch signaling pathway-
GO:0007220TAS-Notch receptor processing-
GO:0007229NAS-integrin-mediated signaling pathway8694785
GO:0007267NAS-cell-cell signaling12714508
GO:0008284IMP-positive regulation of cell proliferation18373975
GO:0010820IMP-positive regulation of T cell chemotaxis18373975
GO:0016485IEA-protein processing-
GO:0022617TAS-extracellular matrix disassembly-
GO:0030307IMP-positive regulation of cell growth18373975
GO:0030335IMP-positive regulation of cell migration18373975
GO:0034612IDA-response to tumor necrosis factor11831872
GO:0042117IMP-monocyte activation11831872
GO:0043312TAS-neutrophil degranulation-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0051088IMP-PMA-inducible membrane protein ectodomain proteolysis18676862
GO:0051089IDA-constitutive protein ectodomain proteolysis12714508
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EFNA2ADAM1010826310958785 Affinity Capture-Western
EFNA2ADAM1010661610958785 Affinity Capture-Western
GRB2ADAM1010914211741929 Affinity Capture-Western
GRB2ADAM1010661611741929 Affinity Capture-Western
LCKADAM1011012411741929 Affinity Capture-Western
LCKADAM1010661611741929 Affinity Capture-Western
MAD2L1ADAM1011026011741929 Affinity Capture-Western
MAD2L1ADAM1010661611741929 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ADAM10C-348T, del-927ins, rs10518984, rs10851639, rs11071385, rs11071386, rs11071392, rs11071393, rs11071397, rs11639204, rs11857405, rs12324536, rs12437457, rs12438487, rs12439231, rs12441313, rs12591291, rs12594872, rs12901512, rs12913383, rs1427280, rs1427281, rs1427282, rs16940472, rs16940571, rs16940602, rs16940629, rs16940651, rs16940712, rs16940751, rs16940810, rs16953389, rs17190678, rs17269341, rs17269348, rs17301795, rs1869133, rs1869135, rs1968687, rs1968689, rs1979178, rs2052805, rs2305421, rs2414598, rs2414599, rs2414607, rs2657125, rs347117, rs3751542, rs383902, rs4238331, rs442495, rs4775083, rs4775085, rs4775086, rs4775096, rs514049, rs593742, rs605928, rs6494025, rs6494030, rs6494031, rs6494036, rs6494038, rs653765, rs664936, rs690, rs714696, rs7161889, rs7163733, rs7164844, rs7165035, rs7166076, rs7166325, rs7171589, rs7174210, rs7174386, rs7179747, rs7180130, rs8026668, rs8028759, rs8029805, rs8035006, rs8036097, rs9302203 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:109548
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040917-2'