AutismKB 2.0

Annotation Details for CDK5


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Basic Information Top
Gene Symbol:CDK5 ( PSSALRE )
Gene Full Name: cyclin-dependent kinase 5
Band: 7q36.1
Quick LinksEntrez ID:1020; OMIM: 123831; Uniprot ID:CDK5_HUMAN; ENSEMBL ID: ENSG00000164885; HGNC ID: 1774
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005634IDA-nucleus-
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0005737ISS-cytoplasm-
GO:0005829IBA-cytosol-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005886IDA-plasma membrane-
GO:0014069ISS-postsynaptic density-
GO:0016020ISS-membrane-
GO:0016533IEA-cyclin-dependent protein kinase 5 holoenzyme complex-
GO:0030027IEA-lamellipodium-
GO:0030054IDA-cell junction-
GO:0030175IEA-filopodium-
GO:0030424ISS-axon-
GO:0030425ISS-dendrite-
GO:0030426ISS-growth cone-
GO:0031594ISS-neuromuscular junction-
GO:0043025ISS-neuronal cell body-
GO:0043204IEA-perikaryon-
GO:0045211IEA-postsynaptic membrane-
GO:0098793IEA-presynapse-
GO ID Evidence Qualifier GO_term References
GO:0002039IEA-p53 binding-
GO:0004672TAS-protein kinase activity1639063
GO:0004674IDA-protein serine/threonine kinase activity20357208
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004693IBA-cyclin-dependent protein serine/threonine kinase activity-
GO:0004693TAS-cyclin-dependent protein serine/threonine kinase activity-
GO:0005176ISS-ErbB-2 class receptor binding-
GO:0005515IPI-protein binding12223541
GO:0005524IEA-ATP binding-
GO:0008092IEA-cytoskeletal protein binding-
GO:0016301ISS-kinase activity-
GO:0019901IEA-protein kinase binding-
GO:0030549ISS-acetylcholine receptor activator activity-
GO:0043125ISS-ErbB-3 class receptor binding-
GO:0046875IEA-ephrin receptor binding-
GO:0050321ISS-tau-protein kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0001764TAS-neuron migration21473899
GO:0001963IEA-synaptic transmission, dopaminergic-
GO:0006886IEA-intracellular protein transport-
GO:0006913IEA-nucleocytoplasmic transport-
GO:0007049IEA-cell cycle-
GO:0007160IEA-cell-matrix adhesion-
GO:0007268TAS-chemical synaptic transmission21473899
GO:0007416TAS-synapse assembly21473899
GO:0007519IEA-skeletal muscle tissue development-
GO:0008045IEA-motor neuron axon guidance-
GO:0008283TAS-cell proliferation8090221
GO:0008542IEA-visual learning-
GO:0009611IEA-response to wounding-
GO:0014044IEA-Schwann cell development-
GO:0016079TAS-synaptic vesicle exocytosis21473899
GO:0016241TAS-regulation of macroautophagy21499257
GO:0016310IDA-phosphorylation20357208
GO:0018105IDA-peptidyl-serine phosphorylation21145489
GO:0018107IEA-peptidyl-threonine phosphorylation-
GO:0019233IEA-sensory perception of pain-
GO:0021697IEA-cerebellar cortex formation-
GO:0021766IEA-hippocampus development-
GO:0021819IEA-layer formation in cerebral cortex-
GO:0021954IEA-central nervous system neuron development-
GO:0022038IEA-corpus callosum development-
GO:0030182ISS-neuron differentiation-
GO:0030182TAS-neuron differentiation21473899
GO:0030334IEA-regulation of cell migration-
GO:0030517IEA-negative regulation of axon extension-
GO:0030866IEA-cortical actin cytoskeleton organization-
GO:0031175ISS-neuron projection development-
GO:0031397IEA-negative regulation of protein ubiquitination-
GO:0031914IEA-negative regulation of synaptic plasticity-
GO:0032092IEA-positive regulation of protein binding-
GO:0032801IEA-receptor catabolic process-
GO:0035249IEA-synaptic transmission, glutamatergic-
GO:0035418IEA-protein localization to synapse-
GO:0042501IEA-serine phosphorylation of STAT protein-
GO:0042981TAS-regulation of apoptotic process21473899
GO:0043113IEA-receptor clustering-
GO:0043525ISS-positive regulation of neuron apoptotic process-
GO:0045786IEA-negative regulation of cell cycle-
GO:0045860IEA-positive regulation of protein kinase activity-
GO:0045861IMP-negative regulation of proteolysis24548080
GO:0045892IMP-negative regulation of transcription, DNA-templated20357208
GO:0045956IEA-positive regulation of calcium ion-dependent exocytosis-
GO:0046777IEA-protein autophosphorylation-
GO:0046826IEA-negative regulation of protein export from nucleus-
GO:0048148IEA-behavioral response to cocaine-
GO:0048167ISS-regulation of synaptic plasticity-
GO:0048167TAS-regulation of synaptic plasticity21473899
GO:0048488TAS-synaptic vesicle endocytosis21473899
GO:0048511IEA-rhythmic process-
GO:0048675TAS-axon extension21473899
GO:0048709IDA-oligodendrocyte differentiation18042622
GO:0048813IEA-dendrite morphogenesis-
GO:0051301IEA-cell division-
GO:0051402TAS-neuron apoptotic process21473899
GO:0060079IEA-excitatory postsynaptic potential-
GO:0061001ISS-regulation of dendritic spine morphogenesis-
GO:0070509IEA-calcium ion import-
GO:0071156TAS-regulation of cell cycle arrest21473899
GO:0090314IEA-positive regulation of protein targeting to membrane-
GO:1901215IDA-negative regulation of neuron death24548080
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:1903421NAS-regulation of synaptic vesicle recycling22745285
GO:2000251TAS-positive regulation of actin cytoskeleton reorganization21473899
GO:2000273IEA-positive regulation of receptor activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDK5BRCA11074559244350 Reconstituted Complex
CDK5BRCA11071409244350 Reconstituted Complex
CDK5CCND21074559422379 Affinity Capture-Western
CDK5CCND21073349422379 Affinity Capture-Western
GAKCDK51088539013862 Affinity Capture-Western
GAKCDK51074559013862 Affinity Capture-Western
STX1ACDK51126769478941 Reconstituted Complex
STX1ACDK51074559478941 Reconstituted Complex
CDK5RAP2CDK512087310915792 Reconstituted Complex
CDK5RAP2CDK510745510915792 Reconstituted Complex
NDEL1CDK512352711163260 Biochemical Activity; Co-localization
NDEL1CDK510745511163260 Biochemical Activity; Co-localization
CDK5R1CDK510745511389014 11583627 17591690 Affinity Capture-Western; Co-crystal Structure
CDK5R1CDK511437611389014 11583627 17591690 Affinity Capture-Western; Co-crystal Structure
PAK1CDK510745511604394 Affinity Capture-Western; Biochemical Activity
PAK1CDK511109511604394 Affinity Capture-Western; Biochemical Activity
CABLES2CDK510745511955625 Affinity Capture-Western
CABLES2CDK512362811955625 Affinity Capture-Western
CDK16CDK511115412084709 Biochemical Activity
CDK16CDK510745512084709 Biochemical Activity
NESCDK511598312832492 Affinity Capture-Western; Biochemical Activity
NESCDK510745512832492 Affinity Capture-Western; Biochemical Activity
LMTK2CDK510745512832520 Reconstituted Complex; Two-hybrid
LMTK2CDK511652412832520 Reconstituted Complex; Two-hybrid
STXBP1CDK510745512963086 Affinity Capture-Western
STXBP1CDK511268112963086 Affinity Capture-Western
HDAC4CDK510745516356933 Affinity Capture-Western
HDAC4CDK511510616356933 Affinity Capture-Western
PARK2CDK511110517327227 Affinity Capture-Western; Biochemical Activity
PARK2CDK510745517327227 Affinity Capture-Western; Biochemical Activity
TP53CDK511301017591690 Affinity Capture-Western; Reconstituted Complex
TP53CDK510745517591690 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CDK5rs1549759, rs2069442, rs2069454, rs2069459, rs891507, rs9278 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
CDK5rs1549760, rs2069459, rs4148852 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:101765
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010131-2'