AutismKB 2.0

Annotation Details for CDK6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDK6 ( MGC59692,PLSTIRE )
Gene Full Name: cyclin-dependent kinase 6
Band: 7q21.2
Quick LinksEntrez ID:1021; OMIM: 603368; Uniprot ID:CDK6_HUMAN; ENSEMBL ID: ENSG00000105810; HGNC ID: 1777
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000307IDA-cyclin-dependent protein kinase holoenzyme complex17420273
GO:0001726IDA-ruffle10205165
GO:0005634IDA-nucleus14985467
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm14985467
GO:0005813IDA-centrosome23918663
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0097132IEA-cyclin D2-CDK6 complex-
GO ID Evidence Qualifier GO_term References
GO:0004693IDA-cyclin-dependent protein serine/threonine kinase activity8114739
GO:0005515IPI-protein binding8001816
GO:0005524IDA-ATP binding9751050
GO:0030332IPI-cyclin binding8114739
GO:0098770IPI-FBXO family protein binding18495667
GO ID Evidence Qualifier GO_term References
GO:0000082TAS-G1/S transition of mitotic cell cycle16294322
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001954IDA-positive regulation of cell-matrix adhesion10205165
GO:0003323IDA-type B pancreatic cell development20668294
GO:0006468IDA-protein phosphorylation8114739
GO:0007050TAS-cell cycle arrest16294322
GO:0007165IBA-signal transduction-
GO:0007219IEA-Notch signaling pathway-
GO:0008285TAS-negative regulation of cell proliferation16294322
GO:0009615IEP-response to virus16548883
GO:0010389IBA-regulation of G2/M transition of mitotic cell cycle-
GO:0010468IDA-regulation of gene expression15254224
GO:0010468IMP-regulation of gene expression17420273
GO:0010628IEA-positive regulation of gene expression-
GO:0014002ISS-astrocyte development16767702
GO:0021542ISS-dentate gyrus development21319271
GO:0021670ISS-lateral ventricle development21319271
GO:0033077IEA-T cell differentiation in thymus-
GO:0042063IMP-gliogenesis12861051
GO:0043697IMP-cell dedifferentiation12861051
GO:0045596TAS-negative regulation of cell differentiation16294322
GO:0045638IDA-negative regulation of myeloid cell differentiation17431401
GO:0045646IMP-regulation of erythrocyte differentiation12833137
GO:0045656IDA-negative regulation of monocyte differentiation26542173
GO:0045668IDA-negative regulation of osteoblast differentiation15254224
GO:0045786IDA-negative regulation of cell cycle14985467
GO:0048146IMP-positive regulation of fibroblast proliferation17420273
GO:0048699ISS-generation of neurons21319271
GO:0050680IMP-negative regulation of epithelial cell proliferation14985467
GO:0051301IEA-cell division-
GO:0060218IEA-hematopoietic stem cell differentiation-
GO:1902036IEA-regulation of hematopoietic stem cell differentiation-
GO:1904628IDA-cellular response to phorbol 13-acetate 12-myristate26542173
GO:2000145ISS-regulation of cell motility16767702
GO:2000773IDA-negative regulation of cellular senescence17420273
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDK6CCND110706710580009 11360184 Affinity Capture-Western; Reconstituted Complex
CDK6CCND110745610580009 11360184 Affinity Capture-Western; Reconstituted Complex
CDK6CCND210745611360184 Affinity Capture-Western
CDK6CCND210733411360184 Affinity Capture-Western
CDK6CCND31074568114739 11360184 Affinity Capture-Western
CDK6CCND31073368114739 11360184 Affinity Capture-Western
CDK6CDK210745610934208 Co-purification
CDK6CDK210745210934208 Co-purification
CDKN2CCDK61074658001816 11124804 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
CDKN2CCDK61074568001816 11124804 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
CDC37CDK61074568666233 Reconstituted Complex
CDC37CDK61163128666233 Reconstituted Complex
CDKN2ACDK61074568805225 9751050 11739795 Co-crystal Structure; Protein-peptide; Reconstituted Complex
CDKN2ACDK61074638805225 9751050 11739795 Co-crystal Structure; Protein-peptide; Reconstituted Complex
CDKN2DCDK61074569751051 Co-crystal Structure
CDKN2DCDK61074669751051 Co-crystal Structure
PPM1BCDK611149010934208 Biochemical Activity; Co-purification
PPM1BCDK610745610934208 Biochemical Activity; Co-purification
PPP2CACDK610745610934208 Biochemical Activity; Co-purification
PPP2CACDK611150710934208 Biochemical Activity; Co-purification
CDKN1BCDK610746111360184 Affinity Capture-Western
CDKN1BCDK610745611360184 Affinity Capture-Western
FBXO7CDK611732618495667 Affinity Capture-Western
FBXO7CDK610745618495667 Affinity Capture-Western
CDKN1ACDK610745620102411 Affinity Capture-Western
CDKN1ACDK610746020102411 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1277162
  • Data Attributes: MGI curated and HomoloGene calculated
No data