AutismKB 2.0

Annotation Details for TOPORS


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Basic Information Top
Gene Symbol:TOPORS ( LUN,P53BP3,RP31,TP53BPL )
Gene Full Name: topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Band: 9p21.1
Quick LinksEntrez ID:10210; OMIM: 609507; Uniprot ID:TOPRS_HUMAN; ENSEMBL ID: ENSG00000197579; HGNC ID: 21653
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IDA-ubiquitin ligase complex15247280
GO:0000922IDA-spindle pole21159800
GO:0000930IDA-gamma-tubulin complex21159800
GO:0005634IDA-nucleus18077445
GO:0005654IDA-nucleoplasm-
GO:0005814IDA-centriole21159800
GO:0005868TAScolocalizes_withcytoplasmic dynein complex21159800
GO:0016605IDA-PML body20188669
GO:0016605IDAcolocalizes_withPML body21159800
GO:0016607IDA-nuclear speck14516784
GO:0030496TAS-midbody21159800
GO:0032391IDA-photoreceptor connecting cilium21159800
GO:0036064IDA-ciliary basal body21159800
GO ID Evidence Qualifier GO_term References
GO:0003677IDA-DNA binding11278651
GO:0003823IPI-antigen binding10415337
GO:0004842IDA-ubiquitin-protein transferase activity18077445
GO:0004842IMP-ubiquitin-protein transferase activity19473992
GO:0005515IPI-protein binding11842245
GO:0019789IDA-SUMO transferase activity17803295
GO:0019789IMP-SUMO transferase activity19473992
GO:0044547IPI-DNA topoisomerase binding10352183
GO:0046872IEA-metal ion binding-
GO:0061630IDA-ubiquitin protein ligase activity15247280
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination15247280
GO:0006351NAS-transcription, DNA-templated10352183
GO:0006511IMP-ubiquitin-dependent protein catabolic process19473992
GO:0006513IDA-protein monoubiquitination15247280
GO:0006974IDA-cellular response to DNA damage stimulus15735665
GO:0008630IDA-intrinsic apoptotic signaling pathway in response to DNA damage20188669
GO:0010842ISS-retina layer formation21159800
GO:0016925IDA-protein sumoylation17803295
GO:0016925IMP-protein sumoylation20188669
GO:0034504IMP-protein localization to nucleus20188669
GO:0035845ISS-photoreceptor cell outer segment organization21159800
GO:0042127IEA-regulation of cell proliferation-
GO:0042771IEA-intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-
GO:0043066ISS-negative regulation of apoptotic process21159800
GO:0043161IMP-proteasome-mediated ubiquitin-dependent protein catabolic process18077445
GO:0045893IEA-positive regulation of transcription, DNA-templated-
GO:0046548ISS-retinal rod cell development21159800
GO:0046549ISS-retinal cone cell development21159800
GO:0051443IDA-positive regulation of ubiquitin-protein transferase activity15247280
GO:0051457IDA-maintenance of protein location in nucleus14516784
GO:0070936IDA-protein K48-linked ubiquitination15247280
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TOPORSPARP110665217803295 Affinity Capture-MS
TOPORSPARP111550517803295 Affinity Capture-MS
TOPORSDDB210801017803295 Affinity Capture-MS
TOPORSDDB211550517803295 Affinity Capture-MS
TOPORSDHX1510802917803295 Affinity Capture-MS
TOPORSDHX1511550517803295 Affinity Capture-MS
TOPORSEEF1A110823717803295 Affinity Capture-MS
TOPORSEEF1A111550517803295 Affinity Capture-MS
TOPORSGTF2I11550517803295 Affinity Capture-MS
TOPORSGTF2I10922417803295 Affinity Capture-MS
TOPORSHNRNPA110942017803295 Affinity Capture-MS
TOPORSHNRNPA111550517803295 Affinity Capture-MS
TOPORSHNRNPL11550517803295 Affinity Capture-MS
TOPORSHNRNPL10943217803295 Affinity Capture-MS
TOPORSHNRNPM11075117803295 Affinity Capture-MS
TOPORSHNRNPM11550517803295 Affinity Capture-MS
TOPORSNONO11090417803295 Affinity Capture-MS
TOPORSNONO11550517803295 Affinity Capture-MS
TOPORSRANGAP111184017803295 Affinity Capture-MS
TOPORSRANGAP111550517803295 Affinity Capture-MS
TOPORSRBBP411186317803295 Affinity Capture-MS
TOPORSRBBP411550517803295 Affinity Capture-MS
TOPORSRBBP711550517803295 Affinity Capture-MS
TOPORSRBBP711186617803295 Affinity Capture-MS
TOPORSS100A911218817803295 Affinity Capture-MS
TOPORSS100A911550517803295 Affinity Capture-MS
TOPORSSFPQ11550517803295 Affinity Capture-MS
TOPORSSFPQ11231917803295 Affinity Capture-MS
TOPORSSMARCC211550517803295 Affinity Capture-MS
TOPORSSMARCC211248517803295 Affinity Capture-MS
TOPORSTOP111300310352183 Affinity Capture-Western; Two-hybrid
TOPORSTOP111550510352183 Affinity Capture-Western; Two-hybrid
TOPORSTP5311301011842245 15247280 17803295 Biochemical Activity; Reconstituted Complex; Two-hybrid
TOPORSTP5311550511842245 15247280 17803295 Biochemical Activity; Reconstituted Complex; Two-hybrid
TOPORSUBE2D111550519053840 19690564 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TOPORSUBE2D111316919053840 19690564 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TOPORSUBE2D211550519690564 Two-hybrid
TOPORSUBE2D211317019690564 Two-hybrid
TOPORSUBE2D311550519690564 Two-hybrid
TOPORSUBE2D311317119690564 Two-hybrid
TOPORSUBE2I11317714516784 Two-hybrid
TOPORSUBE2I11550514516784 Two-hybrid
TOPORSUBE2N11318219690564 Two-hybrid
TOPORSUBE2N11550519690564 Two-hybrid
TOPORSSUMO111318814516784 Two-hybrid
TOPORSSUMO111550514516784 Two-hybrid
TOPORSUBE2L611467219690564 Two-hybrid
TOPORSUBE2L611550519690564 Two-hybrid
TOPORSSAFB211550517803295 Affinity Capture-MS
TOPORSSAFB211502217803295 Affinity Capture-MS
TOPORSTRIM2811545717803295 Affinity Capture-MS
TOPORSTRIM2811550517803295 Affinity Capture-MS
HABP4TOPORS11550516455055 Two-hybrid
HABP4TOPORS11658716455055 Two-hybrid
SF3B1TOPORS11550517803295 Affinity Capture-MS
SF3B1TOPORS11701717803295 Affinity Capture-MS
UPF3ATOPORS11550517803295 Affinity Capture-MS
UPF3ATOPORS12239717803295 Affinity Capture-MS
SIN3ATOPORS11743917803295 Affinity Capture-MS; Biochemical Activity
SIN3ATOPORS11550517803295 Affinity Capture-MS; Biochemical Activity
UBE2J1TOPORS11955519690564 Two-hybrid
UBE2J1TOPORS11550519690564 Two-hybrid
UBE2D4TOPORS11964119690564 Two-hybrid
UBE2D4TOPORS11550519690564 Two-hybrid
UBE2WTOPORS12057219690564 Two-hybrid
UBE2WTOPORS11550519690564 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2146189
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-6401'