AutismKB 2.0

Annotation Details for TRIB1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TRIB1 ( C8FW,GIG2,SKIP1,TRB1 )
Gene Full Name: tribbles homolog 1 (Drosophila)
Band: 8q24.13
Quick LinksEntrez ID:10221; OMIM: 609461; Uniprot ID:TRIB1_HUMAN; ENSEMBL ID: ENSG00000173334; HGNC ID: 16891
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus17452330
GO:0005737IDA-cytoplasm17452330
GO ID Evidence Qualifier GO_term References
GO:0004672TASNOTprotein kinase activity20410507
GO:0004860IMP-protein kinase inhibitor activity15299019
GO:0005515IPI-protein binding25852190
GO:0005524TASNOTATP binding20410507
GO:0008134IPI-transcription factor binding17724128
GO:0031434IDA-mitogen-activated protein kinase kinase binding15299019
GO:0031625ISS-ubiquitin protein ligase binding20410507
GO:0055106ISS-ubiquitin-protein transferase regulator activity20410507
GO ID Evidence Qualifier GO_term References
GO:0006468TASNOTprotein phosphorylation20410507
GO:0006469IMP-negative regulation of protein kinase activity15299019
GO:0007254IMP-JNK cascade17452330
GO:0014912IMP-negative regulation of smooth muscle cell migration17452330
GO:0031665IMP-negative regulation of lipopolysaccharide-mediated signaling pathway17452330
GO:0032436IBA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process-
GO:0032436ISS-positive regulation of proteasomal ubiquitin-dependent protein catabolic process20410507
GO:0032496IMP-response to lipopolysaccharide17452330
GO:0032496ISS-response to lipopolysaccharide17724128
GO:0043405IDA-regulation of MAP kinase activity15299019
GO:0043433IMP-negative regulation of sequence-specific DNA binding transcription factor activity15299019
GO:0043433ISS-negative regulation of sequence-specific DNA binding transcription factor activity17724128
GO:0045645IEA-positive regulation of eosinophil differentiation-
GO:0045651IEA-positive regulation of macrophage differentiation-
GO:0045659IEA-negative regulation of neutrophil differentiation-
GO:0048662IMP-negative regulation of smooth muscle cell proliferation17452330
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRIB1ALOX1211551610727209 Two-hybrid
TRIB1ALOX1210674010727209 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2443397
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-091207-4'