AutismKB 2.0

Annotation Details for CDK8


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Basic Information Top
Gene Symbol:CDK8 ( K35,MGC126074,MGC126075 )
Gene Full Name: cyclin-dependent kinase 8
Band: 13q12.13
Quick LinksEntrez ID:1024; OMIM: 603184; Uniprot ID:CDK8_HUMAN; ENSEMBL ID: ENSG00000132964; HGNC ID: 1779
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16109376
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus22869755
GO:0016592IDA-mediator complex14638676
GO:0043234IDA-protein complex22869755
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity7568034
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004693IBA-cyclin-dependent protein serine/threonine kinase activity-
GO:0005515IPI-protein binding7568034
GO:0005524IEA-ATP binding-
GO:0008353IEA-RNA polymerase II carboxy-terminal domain kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006468IEA-protein phosphorylation-
GO:0007346IBA-regulation of mitotic cell cycle-
GO:0045944TAS-positive regulation of transcription from RNA polymerase II promoter-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDK8PARP110665215808511 16204234 Affinity Capture-Western; Reconstituted Complex
CDK8PARP110745815808511 16204234 Affinity Capture-Western; Reconstituted Complex
CDK8BRCA11074589159119 Co-purification
CDK8BRCA11071409159119 Co-purification
CDK8CCNC1074587568034 9150135 9710619 11416138 11867769 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
CDK8CCNC1073337568034 9150135 9710619 11416138 11867769 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
TCEA1CDK81074589305922 Reconstituted Complex
TCEA1CDK81127799305922 Reconstituted Complex
MED21CDK81074589315662 9710619 10198638 11867769 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
MED21CDK81148079315662 9710619 10198638 11867769 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
KAT2BCDK81143759710619 Affinity Capture-Western
KAT2BCDK81074589710619 Affinity Capture-Western
CREBBPCDK81077779710619 Affinity Capture-Western; Co-fractionation
CREBBPCDK81074589710619 Affinity Capture-Western; Co-fractionation
POLR2ACDK81074589710619 Affinity Capture-Western; Co-fractionation
POLR2ACDK81114269710619 Affinity Capture-Western; Co-fractionation
SMARCB1CDK81074589710619 Affinity Capture-Western; Co-fractionation
SMARCB1CDK81124829710619 Affinity Capture-Western; Co-fractionation
SMARCA2CDK81124799710619 Co-fractionation
SMARCA2CDK81074589710619 Co-fractionation
SMARCC1CDK81074589710619 Co-fractionation
SMARCC1CDK81124839710619 Co-fractionation
SMARCC2CDK81124859710619 Co-fractionation
SMARCC2CDK81074589710619 Co-fractionation
MED31CDK810745810198638 Affinity Capture-MS
MED31CDK811921110198638 Affinity Capture-MS
THRAP3CDK811529210198638 Affinity Capture-MS
THRAP3CDK810745810198638 Affinity Capture-MS
MED6CDK811531910198638 11416138 11867769 14983011 15808511 Affinity Capture-MS; Affinity Capture-Western
MED6CDK810745810198638 11416138 11867769 14983011 15808511 Affinity Capture-MS; Affinity Capture-Western
MED16CDK810745810198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED16CDK811534210198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED1CDK810745810198638 11867769 15989967 Affinity Capture-MS; Affinity Capture-Western
MED1CDK811146510198638 11867769 15989967 Affinity Capture-MS; Affinity Capture-Western
MED10CDK810745810198638 11867769 15175163 15989967 Affinity Capture-MS; Affinity Capture-Western
MED10CDK812397410198638 11867769 15175163 15989967 Affinity Capture-MS; Affinity Capture-Western
MED14CDK810745810198638 11416138 Affinity Capture-MS; Affinity Capture-Western
MED14CDK811469910198638 11416138 Affinity Capture-MS; Affinity Capture-Western
MED17CDK810745810198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED17CDK811483010198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED24CDK811519610198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED24CDK810745810198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED12CDK811529310198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED12CDK810745810198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED13CDK811529410198638 11867769 Affinity Capture-MS; Affinity Capture-Western
MED13CDK810745810198638 11867769 Affinity Capture-MS; Affinity Capture-Western
THRACDK810745810198638 Affinity Capture-Western
THRACDK811292310198638 Affinity Capture-Western
MED23CDK810745811416138 11867769 Affinity Capture-Western
MED23CDK811482911416138 11867769 Affinity Capture-Western
MYCCDK811069411673469 Reconstituted Complex
MYCCDK810745811673469 Reconstituted Complex
MED7CDK810745811867769 Affinity Capture-Western
MED7CDK811483311867769 Affinity Capture-Western
MED20CDK810745811867769 Affinity Capture-Western
MED20CDK811486211867769 Affinity Capture-Western
ESR1CDK810745811867769 Reconstituted Complex
ESR1CDK810840311867769 Reconstituted Complex
ESR2CDK810840411867769 Reconstituted Complex
ESR2CDK810745811867769 Reconstituted Complex
CEBPBCDK810748014759369 Affinity Capture-Western
CEBPBCDK810745814759369 Affinity Capture-Western
MED25CDK810745814983011 Affinity Capture-MS
MED25CDK812360714983011 Affinity Capture-MS
MED19CDK812855315175163 Affinity Capture-MS
MED19CDK810745815175163 Affinity Capture-MS
MED9CDK810745815175163 Affinity Capture-MS
MED9CDK812040315175163 Affinity Capture-MS
MED29CDK812073415175163 Affinity Capture-MS
MED29CDK810745815175163 Affinity Capture-MS
MED28CDK810745815175163 Affinity Capture-MS
MED28CDK812321915175163 Affinity Capture-MS
MED26CDK810745815175163 Affinity Capture-MS; Affinity Capture-Western
MED26CDK811483115175163 Affinity Capture-MS; Affinity Capture-Western
TRRAPCDK811390018418385 Co-purification
TRRAPCDK810745818418385 Co-purification
EHMT2CDK811612318691967 Affinity Capture-Western
EHMT2CDK810745818691967 Affinity Capture-Western
MED30CDK812470718691967 Affinity Capture-Western
MED30CDK810745818691967 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1196224
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030903-2'