AutismKB 2.0

Annotation Details for CDK9


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Basic Information Top
Gene Symbol:CDK9 ( C-2k,CDC2L4,CTK1,PITALRE,TAK )
Gene Full Name: cyclin-dependent kinase 9
Band: 9q34.11
Quick LinksEntrez ID:1025; OMIM: 603251; Uniprot ID:CDK9_HUMAN; ENSEMBL ID: ENSG00000136807; HGNC ID: 1780
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005694IBA-chromosome-
GO:0008023IDA-transcription elongation factor complex22195968
GO:0008024IDA-cyclin/CDK positive transcription elongation factor complex9499409
GO:0016020IDA-membrane19946888
GO:0016605IDA-PML body18250157
GO ID Evidence Qualifier GO_term References
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0001223IPI-transcription coactivator binding12037672
GO:0003677IDA-DNA binding16109376
GO:0003682ISS-chromatin binding-
GO:0004672TAS-protein kinase activity8170997
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004693IDA-cyclin-dependent protein serine/threonine kinase activity12037670
GO:0005515IPI-protein binding9499409
GO:0005524IEA-ATP binding-
GO:0008353IDA-RNA polymerase II carboxy-terminal domain kinase activity12721286
GO:0016301TAS-kinase activity-
GO:0019901IEA-protein kinase binding-
GO:0030332IBA-cyclin binding-
GO:0044212IBA-transcription regulatory region DNA binding-
GO:0097322IDA-7SK snRNA binding11713533
GO ID Evidence Qualifier GO_term References
GO:0006281IEA-DNA repair-
GO:0006282IDA-regulation of DNA repair20493174
GO:0006366TAS-transcription from RNA polymerase II promoter-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter10866664
GO:0006368IBA-transcription elongation from RNA polymerase II promoter-
GO:0006368TAS-transcription elongation from RNA polymerase II promoter-
GO:0006468IDA-protein phosphorylation16109376
GO:0007346IMPNOTregulation of mitotic cell cycle19575011
GO:0008283TAS-cell proliferation8170997
GO:0010613IEA-positive regulation of cardiac muscle hypertrophy-
GO:0031056IDA-regulation of histone modification19844166
GO:0031297IDA-replication fork processing20930849
GO:0033129IMP-positive regulation of histone phosphorylation19575011
GO:0042493IEA-response to drug-
GO:0042795TAS-snRNA transcription from RNA polymerase II promoter-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter19575011
GO:0045944TAS-positive regulation of transcription from RNA polymerase II promoter-
GO:0050434TAS-positive regulation of viral transcription-
GO:0051147IMP-regulation of muscle cell differentiation12037670
GO:0070816IBA-phosphorylation of RNA polymerase II C-terminal domain-
GO:0071157IDA-negative regulation of cell cycle arrest20930849
GO:0071345IDA-cellular response to cytokine stimulus17956865
GO:1900364IMP-negative regulation of mRNA polyadenylation19575011
GO:1903839IDA-positive regulation of mRNA 3'-UTR binding19575011
GO:2001168IMP-positive regulation of histone H2B ubiquitination19575011
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDK9AR10745911266437 Affinity Capture-Western; Reconstituted Complex
CDK9AR10686211266437 Affinity Capture-Western; Reconstituted Complex
CDK9CCNT11074599499409 10574912 10656684 10958691 11689688 12588988 12832472 12944466 15107825 16980611 17643375 17700062 19818711 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
CDK9CCNT11073439499409 10574912 10656684 10958691 11689688 12588988 12832472 12944466 15107825 16980611 17643375 17700062 19818711 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
CDK9CCNT21073449499409 17643375 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CDK9CCNT21074599499409 17643375 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
CDK9CDC3410745911689688 Affinity Capture-Western; Reconstituted Complex
CDK9CDC3410743211689688 Affinity Capture-Western; Reconstituted Complex
CCNKCDK911433910574912 Reconstituted Complex; Two-hybrid
CCNKCDK910745910574912 Reconstituted Complex; Two-hybrid
HSPA1ACDK910953510617616 Affinity Capture-Western
HSPA1ACDK910745910617616 Affinity Capture-Western
MYBL2CDK910745910656684 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex
MYBL2CDK911069010656684 Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex
TP53CDK911301010656684 Phenotypic Suppression
TP53CDK910745910656684 Phenotypic Suppression
CDK9CDK910745910958691 18971272 Biochemical Activity
SUPT5HCDK911269710958691 Biochemical Activity; Reconstituted Complex
SUPT5HCDK910745910958691 Biochemical Activity; Reconstituted Complex
MYCCDK911069411673469 12944920 17700062 19818711 Affinity Capture-Western; Reconstituted Complex
MYCCDK910745911673469 12944920 17700062 19818711 Affinity Capture-Western; Reconstituted Complex
SKP2CDK911239311689688 Affinity Capture-Western
SKP2CDK910745911689688 Affinity Capture-Western
CUL1CDK911403211689688 Affinity Capture-Western
CUL1CDK910745911689688 Affinity Capture-Western
SKP1CDK911239111689688 Affinity Capture-Western; Reconstituted Complex
SKP1CDK910745911689688 Affinity Capture-Western; Reconstituted Complex
RB1CDK910745912037672 Affinity Capture-Western; Reconstituted Complex
RB1CDK911186012037672 Affinity Capture-Western; Reconstituted Complex
AFF4CDK911801612065898 17643375 Affinity Capture-MS; Affinity Capture-Western
AFF4CDK910745912065898 17643375 Affinity Capture-MS; Affinity Capture-Western
RELACDK910745912173051 Affinity Capture-Western; Reconstituted Complex
RELACDK911190212173051 Affinity Capture-Western; Reconstituted Complex
IL6STCDK910745912386808 Reconstituted Complex
IL6STCDK910978612386808 Reconstituted Complex
GRNCDK910745912588988 Affinity Capture-Western
GRNCDK910915312588988 Affinity Capture-Western
HEXIM1CDK911586012832472 16980611 17643375 Affinity Capture-MS; Affinity Capture-Western
HEXIM1CDK910745912832472 16980611 17643375 Affinity Capture-MS; Affinity Capture-Western
MDFICCDK911900212944466 Affinity Capture-Western; Reconstituted Complex
MDFICCDK910745912944466 Affinity Capture-Western; Reconstituted Complex
NUFIP1CDK911780715107825 Affinity Capture-Western
NUFIP1CDK910745915107825 Affinity Capture-Western
STAT3CDK911265115286705 Affinity Capture-Western; Reconstituted Complex
STAT3CDK910745915286705 Affinity Capture-Western; Reconstituted Complex
BRD4CDK911703616109376 16980611 17643375 18039861 Affinity Capture-MS; Affinity Capture-Western
BRD4CDK910745916109376 16980611 17643375 18039861 Affinity Capture-MS; Affinity Capture-Western
TATCDK911276116601680 Affinity Capture-Western
TATCDK910745916601680 Affinity Capture-Western
POLR2ACDK910745916735508 Biochemical Activity
POLR2ACDK911142616735508 Biochemical Activity
PMS1CDK910745917148452 Affinity Capture-Western
PMS1CDK911139117148452 Affinity Capture-Western
TRIM28CDK911545717643375 Affinity Capture-MS
TRIM28CDK910745917643375 Affinity Capture-MS
HNRNPRCDK911553017643375 Affinity Capture-MS
HNRNPRCDK910745917643375 Affinity Capture-MS
TUBB2CCDK911565617643375 Affinity Capture-MS
TUBB2CCDK910745917643375 Affinity Capture-MS
SYNCRIPCDK911575517643375 Affinity Capture-MS
SYNCRIPCDK910745917643375 Affinity Capture-MS
CCT4CDK911582617643375 Affinity Capture-MS
CCT4CDK910745917643375 Affinity Capture-MS
ARID3BCDK911586517643375 Affinity Capture-MS
ARID3BCDK910745917643375 Affinity Capture-MS
IGF2BP1CDK910745917643375 Affinity Capture-MS
IGF2BP1CDK911588617643375 Affinity Capture-MS
IGF2BP2CDK910745917643375 Affinity Capture-MS
IGF2BP2CDK911588817643375 Affinity Capture-MS
CCT8CDK911593317643375 Affinity Capture-MS
CCT8CDK910745917643375 Affinity Capture-MS
RUVBL2CDK911606717643375 Affinity Capture-MS
RUVBL2CDK910745917643375 Affinity Capture-MS
HNRNPA0CDK910745917643375 Affinity Capture-MS
HNRNPA0CDK911614917643375 Affinity Capture-MS
SNRPD2P1CDK912563517643375 Affinity Capture-MS
SNRPD2P1CDK910745917643375 Affinity Capture-MS
HEXIM2CDK912588817643375 Affinity Capture-MS
HEXIM2CDK910745917643375 Affinity Capture-MS
CSNK2BCDK910745917643375 Affinity Capture-MS
CSNK2BCDK910784317643375 Affinity Capture-MS
DDX5CDK910745917643375 Affinity Capture-MS
DDX5CDK910802117643375 Affinity Capture-MS
DTYMKCDK910817417643375 Affinity Capture-MS
DTYMKCDK910745917643375 Affinity Capture-MS
FKBP5CDK910745917643375 Affinity Capture-MS
FKBP5CDK910857917643375 Affinity Capture-MS
CCT5CDK911660317643375 Affinity Capture-MS
CCT5CDK910745917643375 Affinity Capture-MS
MRPS27CDK911673117643375 Affinity Capture-MS
MRPS27CDK910745917643375 Affinity Capture-MS
HNRNPA1CDK910745917643375 Affinity Capture-MS
HNRNPA1CDK910942017643375 Affinity Capture-MS
HNRNPA2B1CDK910745917643375 Affinity Capture-MS
HNRNPA2B1CDK910942217643375 Affinity Capture-MS
HNRNPDCDK910745917643375 Affinity Capture-MS
HNRNPDCDK910942517643375 Affinity Capture-MS
HNRNPH1CDK910745917643375 Affinity Capture-MS
HNRNPH1CDK910942817643375 Affinity Capture-MS
HNRNPKCDK910745917643375 Affinity Capture-MS
HNRNPKCDK910943117643375 Affinity Capture-MS
HNRNPUCDK910745917643375 Affinity Capture-MS
HNRNPUCDK910943317643375 Affinity Capture-MS
HSPA2CDK910953817643375 Affinity Capture-MS
HSPA2CDK910745917643375 Affinity Capture-MS
HSPA5CDK910745917643375 Affinity Capture-MS
HSPA5CDK910954117643375 Affinity Capture-MS
HSPA6CDK910745917643375 Affinity Capture-MS
HSPA6CDK910954217643375 Affinity Capture-MS
HSP90AB1CDK910955817643375 Affinity Capture-MS
HSP90AB1CDK910745917643375 Affinity Capture-MS
HSPD1CDK910745917643375 Affinity Capture-MS
HSPD1CDK910956117643375 Affinity Capture-MS
ILF2CDK910982117643375 Affinity Capture-MS
ILF2CDK910745917643375 Affinity Capture-MS
KPNA2CDK911003617643375 Affinity Capture-MS
KPNA2CDK910745917643375 Affinity Capture-MS
LOC440264CDK913641517643375 Affinity Capture-MS
LOC440264CDK910745917643375 Affinity Capture-MS
YBX1CDK910745917643375 Affinity Capture-MS
YBX1CDK911095917643375 Affinity Capture-MS
PCBP2CDK911112717643375 Affinity Capture-MS
PCBP2CDK910745917643375 Affinity Capture-MS
LARP7CDK911961917643375 Affinity Capture-MS
LARP7CDK910745917643375 Affinity Capture-MS
CCDC87CDK912052617643375 Affinity Capture-MS
CCDC87CDK910745917643375 Affinity Capture-MS
MEPCECDK912112217643375 Affinity Capture-MS
MEPCECDK910745917643375 Affinity Capture-MS
EXOSC5CDK912124317643375 Affinity Capture-MS
EXOSC5CDK910745917643375 Affinity Capture-MS
KIAA1967CDK912177517643375 Affinity Capture-MS
KIAA1967CDK910745917643375 Affinity Capture-MS
RFC4CDK910745917643375 Affinity Capture-MS
RFC4CDK911191617643375 Affinity Capture-MS
RPS4XCDK910745917643375 Affinity Capture-MS
RPS4XCDK911210517643375 Affinity Capture-MS
CCT3CDK911305417643375 Affinity Capture-MS
CCT3CDK910745917643375 Affinity Capture-MS
CDC73CDK912272417643375 Affinity Capture-MS
CDC73CDK910745917643375 Affinity Capture-MS
UBL4ACDK910745917643375 Affinity Capture-MS
UBL4ACDK911388517643375 Affinity Capture-MS
RUVBL1CDK911416617643375 Affinity Capture-MS
RUVBL1CDK910745917643375 Affinity Capture-MS
RQCD1CDK911457317643375 Affinity Capture-MS
RQCD1CDK910745917643375 Affinity Capture-MS
TRIP12CDK911473117643375 Affinity Capture-MS
TRIP12CDK910745917643375 Affinity Capture-MS
RBM39CDK911495217643375 Affinity Capture-MS
RBM39CDK910745917643375 Affinity Capture-MS
SART3CDK910745917643375 Affinity Capture-MS
SART3CDK911508217643375 Affinity Capture-MS
MATR3CDK910745917643375 Affinity Capture-MS
MATR3CDK911512617643375 Affinity Capture-MS
CKAP5CDK911513717643375 Affinity Capture-MS
CKAP5CDK910745917643375 Affinity Capture-MS
PGCCDK911124618200011 Affinity Capture-Western
PGCCDK910745918200011 Affinity Capture-Western
SNW1CDK911659719818711 Affinity Capture-Western
SNW1CDK910745919818711 Affinity Capture-Western
MLLT1CDK911044419956800 Affinity Capture-Western
MLLT1CDK910745919956800 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
CDK9CCNT11805159499409 CyclinT1 interacts with Cdk9.
CDK9CCNT121509212588988 Cyclin T1 interacts with CDK9.
CDK9CCNT118516615546612 CycT1 interacts with CDK9. This interaction was modeled on a demonstrated interaction between CycT1 from an unspecified species and human CDK9.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1328368
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-321'