Gene Symbol:	SPRY2 ( MGC23039,hSPRY2 )
Gene Full Name:	sprouty homolog 2 (Drosophila)
Band:	13q31.1
Quick Links	Entrez ID:10253; OMIM: 602466; Uniprot ID:SPY2_HUMAN; ENSEMBL ID: ENSG00000136158; HGNC ID: 11270
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	ISS	-	nucleus	-
GO:0005829	ISS	-	cytosol	-
GO:0005829	TAS	-	cytosol	-
GO:0005856	ISS	-	cytoskeleton	-
GO:0005874	IEA	-	microtubule	-
GO:0005886	TAS	-	plasma membrane	-
GO:0015630	IDA	-	microtubule cytoskeleton	-
GO:0016020	ISS	-	membrane	-
GO:0032587	IEA	-	ruffle membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005515	IPI	-	protein binding	12815057
GO:0019901	IPI	-	protein kinase binding	20736167
GO:0030291	IC	-	protein serine/threonine kinase inhibitor activity	20736167
GO:0043539	IMP	-	protein serine/threonine kinase activator activity	18070883

GO ID	Evidence	Qualifier	GO_term	References
GO:0000132	IEA	-	establishment of mitotic spindle orientation	-
GO:0007605	IEA	-	sensory perception of sound	-
GO:0008285	IEA	-	negative regulation of cell proliferation	-
GO:0010628	IMP	-	positive regulation of gene expression	18070883
GO:0010801	IDA	-	negative regulation of peptidyl-threonine phosphorylation	20736167
GO:0030335	IMP	-	positive regulation of cell migration	20489163
GO:0031345	ISS	-	negative regulation of cell projection organization	-
GO:0033138	IMP	-	positive regulation of peptidyl-serine phosphorylation	18070883
GO:0034260	IEA	-	negative regulation of GTPase activity	-
GO:0040037	IEA	-	negative regulation of fibroblast growth factor receptor signaling pathway	-
GO:0042059	TAS	-	negative regulation of epidermal growth factor receptor signaling pathway	-
GO:0042472	IEA	-	inner ear morphogenesis	-
GO:0043066	IMP	-	negative regulation of apoptotic process	18070883
GO:0043407	IEA	-	negative regulation of MAP kinase activity	-
GO:0045165	IEA	-	cell fate commitment	-
GO:0045595	IEA	-	regulation of cell differentiation	-
GO:0046580	IEA	-	negative regulation of Ras protein signal transduction	-
GO:0051387	IEA	-	negative regulation of neurotrophin TRK receptor signaling pathway	-
GO:0051897	IMP	-	positive regulation of protein kinase B signaling	18070883
GO:0060437	IEA	-	lung growth	-
GO:0060449	IEA	-	bud elongation involved in lung branching	-
GO:0070373	IMP	-	negative regulation of ERK1 and ERK2 cascade	20489163
GO:0070373	ISS	-	negative regulation of ERK1 and ERK2 cascade	-
GO:0070374	IMP	-	positive regulation of ERK1 and ERK2 cascade	18070883
GO:0071902	IEA	-	positive regulation of protein serine/threonine kinase activity	-

Gene Symbol	Interactant	Interaction ID	References	Description
SPRY2	CBL	115547	11053437 11983899 12234920 12593795 12593796 16246327 17974561 18273061	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
SPRY2	CBL	107315	11053437 11983899 12234920 12593795 12593796 16246327 17974561 18273061	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
SPRY2	EGFR	108276	11983899	Affinity Capture-Western
SPRY2	EGFR	115547	11983899	Affinity Capture-Western
SPRY2	GRB2	109142	10940627 17974561	Affinity Capture-Western; Reconstituted Complex
SPRY2	GRB2	115547	10940627 17974561	Affinity Capture-Western; Reconstituted Complex
SPRY2	PLSCR1	111373	16189514	Two-hybrid
SPRY2	PLSCR1	115547	16189514	Two-hybrid
SPRY2	PPP2CA	111507	17974561	Affinity Capture-Western
SPRY2	PPP2CA	115547	17974561	Affinity Capture-Western
SPRY2	MAPK1	111580	11983899	Affinity Capture-Western
SPRY2	MAPK1	115547	11983899	Affinity Capture-Western
SPRY2	RAF1	115547	12717443	Affinity Capture-Western
SPRY2	RAF1	111831	12717443	Affinity Capture-Western
SPRY2	TESK1	112875	17974561	Affinity Capture-Western
SPRY2	TESK1	115547	17974561	Affinity Capture-Western
SPRY2	TRAF2	115547	16189514	Two-hybrid
SPRY2	TRAF2	113038	16189514	Two-hybrid
SPRY2	UBC	113164	12593796	Affinity Capture-Western
SPRY2	UBC	115547	12593796	Affinity Capture-Western
SPRY2	GPRIN2	115547	16189514	Two-hybrid
SPRY2	GPRIN2	115070	16189514	Two-hybrid
ADAMTSL4	SPRY2	115547	16189514	Two-hybrid
ADAMTSL4	SPRY2	120002	16189514	Two-hybrid
KRTAP4-12	SPRY2	115547	16189514	Two-hybrid
KRTAP4-12	SPRY2	123756	16189514	Two-hybrid
SPRYD5	SPRY2	124248	16189514	Two-hybrid
SPRYD5	SPRY2	115547	16189514	Two-hybrid

AutismKB 2.0

Annotation Details for SPRY2

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics