AutismKB 2.0

Annotation Details for CDKN1A


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Basic Information Top
Gene Symbol:CDKN1A ( CAP20,CDKN1,CIP1,MDA-6,P21,SDI1,WAF1,p21CIP1 )
Gene Full Name: cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Band: 6p21.2
Quick LinksEntrez ID:1026; OMIM: 116899; Uniprot ID:CDN1A_HUMAN; ENSEMBL ID: ENSG00000124762; HGNC ID: 1784
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000307IDA-cyclin-dependent protein kinase holoenzyme complex17420273
GO:0005634IDA-nucleus11343236
GO:0005654IDA-nucleoplasm22869755
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus22869755
GO:0005829TAS-cytosol-
GO:0016604IDA-nuclear body-
GO:0043234IDA-protein complex22869755
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070557IDA-PCNA-p21 complex18794347
GO ID Evidence Qualifier GO_term References
GO:0004693EXP-cyclin-dependent protein serine/threonine kinase activity9190208
GO:0004860IMP-protein kinase inhibitor activity8876165
GO:0004861TAS-cyclin-dependent protein serine/threonine kinase inhibitor activity7958916
GO:0005515IPI-protein binding8756624
GO:0019901IPI-protein kinase binding8876165
GO:0019912IDA-cyclin-dependent protein kinase activating kinase activity9106657
GO:0030332IEA-cyclin binding-
GO:0031625IPI-ubiquitin protein ligase binding23026136
GO:0032403IPI-protein complex binding8876165
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000079TAS-regulation of cyclin-dependent protein serine/threonine kinase activity8242751
GO:0000082IDA-G1/S transition of mitotic cell cycle10208428
GO:0000082TAS-G1/S transition of mitotic cell cycle-
GO:0000086IMP-G2/M transition of mitotic cell cycle17553787
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter-
GO:0006974IMP-cellular response to DNA damage stimulus20160708
GO:0006977IDA-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest15149599
GO:0006977TAS-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-
GO:0006978IEA-DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator-
GO:0007050IDA-cell cycle arrest15149599
GO:0007050IMP-cell cycle arrest17553787
GO:0007265IEP-Ras protein signal transduction9054499
GO:0008285IDA-negative regulation of cell proliferation10208428
GO:0008285IMP-negative regulation of cell proliferation17553787
GO:0009636IEA-response to toxic substance-
GO:0010165IEA-response to X-ray-
GO:0010243IEA-response to organonitrogen compound-
GO:0010629IEA-negative regulation of gene expression-
GO:0030308IDA-negative regulation of cell growth10208428
GO:0030890IEA-positive regulation of B cell proliferation-
GO:0031100IEA-animal organ regeneration-
GO:0031668IMP-cellular response to extracellular stimulus17553787
GO:0033158IEA-regulation of protein import into nucleus, translocation-
GO:0034198IMP-cellular response to amino acid starvation26102367
GO:0034605IEA-cellular response to heat-
GO:0042326IDA-negative regulation of phosphorylation10208428
GO:0042493IEA-response to drug-
GO:0042771IEA-intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043068IEA-positive regulation of programmed cell death-
GO:0045736IEA-negative regulation of cyclin-dependent protein serine/threonine kinase activity-
GO:0045860IDA-positive regulation of protein kinase activity22869755
GO:0046685IEA-response to arsenic-containing substance-
GO:0048146IMP-positive regulation of fibroblast proliferation17420273
GO:0050821TAS-protein stabilization-
GO:0051412IEA-response to corticosterone-
GO:0055093IEA-response to hyperoxia-
GO:0060574IEA-intestinal epithelial cell maturation-
GO:0071479IMP-cellular response to ionizing radiation20160708
GO:0071480IEA-cellular response to gamma radiation-
GO:0071493ISS-cellular response to UV-B-
GO:0071850IEA-mitotic cell cycle arrest-
GO:0090398IMP-cellular senescence15149599
GO:0090399IEA-replicative senescence-
GO:0090400TAS-stress-induced premature senescence20160708
GO:0097193TAS-intrinsic apoptotic signaling pathway9660939
GO:1904030IMP-negative regulation of cyclin-dependent protein kinase activity8876165
GO:1904031IEA-positive regulation of cyclin-dependent protein kinase activity-
GO:2000134IGI-negative regulation of G1/S transition of mitotic cell cycle21628527
GO:2000278IEA-regulation of DNA biosynthetic process-
GO:2000379IMP-positive regulation of reactive oxygen species metabolic process20160708
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDKN1APARP110665212930846 Reconstituted Complex
CDKN1APARP110746012930846 Reconstituted Complex
CDKN1ACCND11070678657154 15695403 16082198 Affinity Capture-Western; Reconstituted Complex
CDKN1ACCND11074608657154 15695403 16082198 Affinity Capture-Western; Reconstituted Complex
CDKN1ACCNA210733112947099 17679094 Affinity Capture-Western
CDKN1ACCNA210746012947099 17679094 Affinity Capture-Western
CDKN1ACCNB110733216082198 17679094 Affinity Capture-Western; Reconstituted Complex
CDKN1ACCNB110746016082198 17679094 Affinity Capture-Western; Reconstituted Complex
CDKN1ACCND210733416189514 Two-hybrid
CDKN1ACCND210746016189514 Two-hybrid
CDKN1ACCND310733616189514 Two-hybrid
CDKN1ACCND310746016189514 Two-hybrid
CDKN1ACCNE110733812839982 Affinity Capture-Western
CDKN1ACCNE110746012839982 Affinity Capture-Western
CDKN1ACDK110746017679094 Affinity Capture-Western
CDKN1ACDK110742017679094 Affinity Capture-Western
CDKN1ACDC2010742717679094 Affinity Capture-Western
CDKN1ACDC2010746017679094 Affinity Capture-Western
CDKN1ACDC2710743117679094 Affinity Capture-Western
CDKN1ACDC2710746017679094 Affinity Capture-Western
CDKN1ACDK21074528242751 9858587 10878006 12417722 12839982 15557281 15647383 20102411 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDKN1ACDK21074608242751 9858587 10878006 12417722 12839982 15557281 15647383 20102411 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDKN1ACDK410745415695403 20102411 Affinity Capture-Western
CDKN1ACDK410746015695403 20102411 Affinity Capture-Western
CDKN1ACDK610745620102411 Affinity Capture-Western
CDKN1ACDK610746020102411 Affinity Capture-Western
PCNACDKN1A1111428861913 8861969 9465025 9545252 11313979 11350925 12930846 16082198 16189514 16474839 17115032 17588519 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
PCNACDKN1A1074608861913 8861969 9465025 9545252 11313979 11350925 12930846 16082198 16189514 16474839 17115032 17588519 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
GADD45GCDKN1A10746010455148 11022036 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GADD45GCDKN1A11611710455148 11022036 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CIZ1CDKN1A10746010529385 Affinity Capture-Western; Two-hybrid
CIZ1CDKN1A11732510529385 Affinity Capture-Western; Two-hybrid
HERC5CDKN1A11936510581175 Reconstituted Complex
HERC5CDKN1A10746010581175 Reconstituted Complex
CSNK2BCDKN1A10746010679299 Reconstituted Complex
CSNK2BCDKN1A10784310679299 Reconstituted Complex
STAT3CDKN1A10746010764767 Affinity Capture-Western
STAT3CDKN1A11265110764767 Affinity Capture-Western
BCCIPCDKN1A10746010878006 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCCIPCDKN1A12116110878006 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GADD45ACDKN1A10801410912791 10973963 Affinity Capture-Western; Reconstituted Complex
GADD45ACDKN1A10746010912791 10973963 Affinity Capture-Western; Reconstituted Complex
PSMA3CDKN1A11165711350925 Reconstituted Complex
PSMA3CDKN1A10746011350925 Reconstituted Complex
TK1CDKN1A10746011389691 Affinity Capture-Western; Reconstituted Complex
TK1CDKN1A11293811389691 Affinity Capture-Western; Reconstituted Complex
CHEK1CDKN1A10753611896572 Affinity Capture-Western
CHEK1CDKN1A10746011896572 Affinity Capture-Western
TP53CDKN1A11301011896572 Affinity Capture-Western
TP53CDKN1A10746011896572 Affinity Capture-Western
TSG101CDKN1A11310211943869 Affinity Capture-Western; Two-hybrid
TSG101CDKN1A10746011943869 Affinity Capture-Western; Two-hybrid
UBCCDKN1A10746012052868 14761977 16262255 17477906 Affinity Capture-Western; Reconstituted Complex
UBCCDKN1A11316412052868 14761977 16262255 17477906 Affinity Capture-Western; Reconstituted Complex
SETCDKN1A10746012407107 16474839 Reconstituted Complex
SETCDKN1A11231612407107 16474839 Reconstituted Complex
PIM1CDKN1A11131012431783 Biochemical Activity; Reconstituted Complex
PIM1CDKN1A10746012431783 Biochemical Activity; Reconstituted Complex
MAP3K5CDKN1A11038112820963 Affinity Capture-Western
MAP3K5CDKN1A10746012820963 Affinity Capture-Western
RNF144BCDKN1A12910612853982 Affinity Capture-Western; Reconstituted Complex
RNF144BCDKN1A10746012853982 Affinity Capture-Western; Reconstituted Complex
MDM2CDKN1A11035814761977 Affinity Capture-Western; Reconstituted Complex
MDM2CDKN1A10746014761977 Affinity Capture-Western; Reconstituted Complex
CREBBPCDKN1A10777715743834 Affinity Capture-Western
CREBBPCDKN1A10746015743834 Affinity Capture-Western
ESR1CDKN1A10746015743834 Reconstituted Complex
ESR1CDKN1A10840315743834 Reconstituted Complex
E2F1CDKN1A10820115964998 Co-localization
E2F1CDKN1A10746015964998 Co-localization
HDAC1CDKN1A10931516082198 20154723 Affinity Capture-Western; Reconstituted Complex
HDAC1CDKN1A10746016082198 20154723 Affinity Capture-Western; Reconstituted Complex
HDAC6CDKN1A10746016082198 Reconstituted Complex
HDAC6CDKN1A11533016082198 Reconstituted Complex
HDAC2CDKN1A10931616082198 Reconstituted Complex
HDAC2CDKN1A10746016082198 Reconstituted Complex
HDAC4CDKN1A10746016082198 Reconstituted Complex
HDAC4CDKN1A11510616082198 Reconstituted Complex
GNB2L1CDKN1A10746016169070 Two-hybrid
GNB2L1CDKN1A11567116169070 Two-hybrid
GET4CDKN1A10746016169070 Two-hybrid
GET4CDKN1A11963616169070 Two-hybrid
RAB1ACDKN1A11179916169070 Two-hybrid
RAB1ACDKN1A10746016169070 Two-hybrid
HDAC11CDKN1A10746016169070 Two-hybrid
HDAC11CDKN1A12297016169070 Two-hybrid
CCDC85BCDKN1A10746016189514 Two-hybrid
CCDC85BCDKN1A11619816189514 Two-hybrid
TEX11CDKN1A10746016189514 Two-hybrid
TEX11CDKN1A12109316189514 Two-hybrid
MGMTCDKN1A11041116226712 Affinity Capture-Western
MGMTCDKN1A10746016226712 Affinity Capture-Western
GAPDHCDKN1A10886816474839 Affinity Capture-MS; Reconstituted Complex
GAPDHCDKN1A10746016474839 Affinity Capture-MS; Reconstituted Complex
SKP2CDKN1A10746017477906 17679094 Affinity Capture-Western
SKP2CDKN1A11239317477906 17679094 Affinity Capture-Western
PSME3CDKN1A10746017588519 Affinity Capture-Western
PSME3CDKN1A11549217588519 Affinity Capture-Western
EP300CDKN1A10834718263614 Affinity Capture-Western; Reconstituted Complex
EP300CDKN1A10746018263614 Affinity Capture-Western; Reconstituted Complex
DDB1CDKN1A10800918703516 18794347 Affinity Capture-Western
DDB1CDKN1A10746018703516 18794347 Affinity Capture-Western
DTLCDKN1A10746018703516 18794347 Affinity Capture-Western; Biochemical Activity
DTLCDKN1A11958218703516 18794347 Affinity Capture-Western; Biochemical Activity
CUL4ACDKN1A11402918794347 Affinity Capture-Western
CUL4ACDKN1A10746018794347 Affinity Capture-Western
JUNCDKN1A10992820102411 Affinity Capture-Western
JUNCDKN1A10746020102411 Affinity Capture-Western
MAPK8CDKN1A11158520102411 Affinity Capture-Western
MAPK8CDKN1A10746020102411 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
CDKN1ACCNA22584368662825 CDKN1A (p21) interacts with CCNA2 (cyclin A).
CDKN1ACCNA21972189632134 p21 interacts with cyclin A.
CDKN1ACCNA231595716009130 cyclin A interacts with p21. This interaction was modeled on a demonstrated interaction between monkey cyclin A and monkey p21.
CDKN1ACCNE12584378662825 CDKN1A (p21) interacts with CCNE1 (cyclin E).
CDKN1ACCNE11972199632134 p21 interacts with cyclin E.
CDKN1ACDK23009177780738 p21WAF1 interacts with an unspecified isoform of Cdk2. This interaction was modelled on a demonstrated interaction between human p21WAF1 and Cdk2 from an unspecified species.
CDKN1ACDK21963409467962 p21 interacts with CDK2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDK2.
CDKN1ACDK21970569546435 p21 interacts with Cdk2.
CDKN1ACDK230097611302688 p21 interacts with an unspecified isoform of Cdk2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104556
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070705-7'