AutismKB 2.0

Annotation Details for STUB1


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Basic Information Top
Gene Symbol:STUB1 ( CHIP,HSPABP2,NY-CO-7,SDCCAG7,UBOX1 )
Gene Full Name: STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Band: 16p13.3
Quick LinksEntrez ID:10273; OMIM: 607207; Uniprot ID:CHIP_HUMAN; ENSEMBL ID: ENSG00000103266; HGNC ID: 11427
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IDA-ubiquitin ligase complex12150907
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm10330192
GO:0005783IDA-endoplasmic reticulum12150907
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0030018IEA-Z disc-
GO:0031371TAS-ubiquitin conjugating enzyme complex16307917
GO:0042405IDA-nuclear inclusion body16831871
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0001664IPI-G-protein coupled receptor binding12150907
GO:0004842IDA-ubiquitin-protein transferase activity15466472
GO:0004842IMP-ubiquitin-protein transferase activity19713937
GO:0004842TAS-ubiquitin-protein transferase activity16307917
GO:0005515IPI-protein binding11146632
GO:0019899IPI-enzyme binding16280320
GO:0019900IPI-kinase binding17512523
GO:0030544IDA-Hsp70 protein binding10330192
GO:0030544IPI-Hsp70 protein binding24613385
GO:0030674TAS-protein binding, bridging16307917
GO:0030911IDA-TPR domain binding11146632
GO:0031625IPI-ubiquitin protein ligase binding12150907
GO:0034450ISS-ubiquitin-ubiquitin ligase activity-
GO:0042803IDA-protein homodimerization activity23990462
GO:0042803ISS-protein homodimerization activity-
GO:0046332IDA-SMAD binding15781469
GO:0046332IPI-SMAD binding24613385
GO:0051787IDA-misfolded protein binding16831871
GO:0051879IDA-Hsp90 protein binding11146632
GO:0061630IDA-ubiquitin protein ligase activity16275660
GO:0061630IMP-ubiquitin protein ligase activity16809764
GO:1904264IMP-ubiquitin protein ligase activity involved in ERAD pathway23990462
GO ID Evidence Qualifier GO_term References
GO:0000209IDA-protein polyubiquitination15781469
GO:0000209IMP-protein polyubiquitination19713937
GO:0006281IEA-DNA repair-
GO:0006511IMP-ubiquitin-dependent protein catabolic process19713937
GO:0006515IDA-misfolded or incompletely synthesized protein catabolic process16831871
GO:0016567IDA-protein ubiquitination16809764
GO:0016567IMP-protein ubiquitination16809764
GO:0030433IEA-ubiquitin-dependent ERAD pathway-
GO:0030512IMP-negative regulation of transforming growth factor beta receptor signaling pathway24613385
GO:0030512TAS-negative regulation of transforming growth factor beta receptor signaling pathway-
GO:0030579IDA-ubiquitin-dependent SMAD protein catabolic process15781469
GO:0030968IEA-endoplasmic reticulum unfolded protein response-
GO:0031398IDA-positive regulation of protein ubiquitination11146632
GO:0031647IDA-regulation of protein stability16809764
GO:0031943IDA-regulation of glucocorticoid metabolic process11146632
GO:0032091IEA-negative regulation of protein binding-
GO:0032436IDA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process11146632
GO:0038128TAS-ERBB2 signaling pathway-
GO:0042787IMP-protein ubiquitination involved in ubiquitin-dependent protein catabolic process23990462
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process15781469
GO:0051443IEA-positive regulation of ubiquitin-protein transferase activity-
GO:0051604TAS-protein maturation16307917
GO:0051865IDA-protein autoubiquitination16307917
GO:0070534IDA-protein K63-linked ubiquitination16307917
GO:0071218IDA-cellular response to misfolded protein16831871
GO:0090035IDA-positive regulation of chaperone-mediated protein complex assembly16831871
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
STUB1AHR10669917209571 Affinity Capture-Western
STUB1AHR11556317209571 Affinity Capture-Western
STUB1AKT110671018292230 Affinity Capture-Western
STUB1AKT111556318292230 Affinity Capture-Western
STUB1XIAP10682819011619 Reconstituted Complex
STUB1XIAP11556319011619 Reconstituted Complex
STUB1BAG111556311676916 15538384 Affinity Capture-Western; Reconstituted Complex
STUB1BAG110704911676916 15538384 Affinity Capture-Western; Reconstituted Complex
STUB1RUNX210730818541707 Affinity Capture-Western; Two-hybrid
STUB1RUNX211556318541707 Affinity Capture-Western; Two-hybrid
STUB1CFTR10750615611333 Biochemical Activity
STUB1CFTR11556315611333 Biochemical Activity
STUB1CYP3A410794819103148 Biochemical Activity
STUB1CYP3A411556319103148 Biochemical Activity
STUB1EGFR10827620029029 PCA
STUB1EGFR11556320029029 PCA
STUB1EIF4E10829216720573 Affinity Capture-Western
STUB1EIF4E11556316720573 Affinity Capture-Western
STUB1ERBB210837612239347 Affinity Capture-Western
STUB1ERBB211556312239347 Affinity Capture-Western
STUB1ESR110840315538384 16037132 Affinity Capture-Western; Reconstituted Complex
STUB1ESR111556315538384 16037132 Affinity Capture-Western; Reconstituted Complex
STUB1GPR3710911912150907 Affinity Capture-Western
STUB1GPR3711556312150907 Affinity Capture-Western
STUB1GUCY1A210923217873020 Affinity Capture-Western; Biochemical Activity
STUB1GUCY1A211556317873020 Affinity Capture-Western; Biochemical Activity
STUB1HSPA1A10953510330192 12150907 Affinity Capture-Western; Reconstituted Complex
STUB1HSPA1A11556310330192 12150907 Affinity Capture-Western; Reconstituted Complex
STUB1HSPA410954010330192 15538384 16169850 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1HSPA411556310330192 15538384 16169850 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1HSPA810954410330192 11557750 15538384 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
STUB1HSPA811556310330192 11557750 15538384 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
STUB1HSP90AA110955215538384 16307917 17324930 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1HSP90AA111556315538384 16307917 17324930 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1DNAJB110956910330192 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1DNAJB111556310330192 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1MAPT11030814962978 15447663 18292230 Affinity Capture-Western; Biochemical Activity
STUB1MAPT11556314962978 15447663 18292230 Affinity Capture-Western; Biochemical Activity
STUB1MCF211556317178836 Reconstituted Complex
STUB1MCF211033617178836 Reconstituted Complex
STUB1MAP3K511556316038411 17595347 Affinity Capture-Western
STUB1MAP3K511038116038411 17595347 Affinity Capture-Western
STUB1MEN111038415254225 Affinity Capture-Western
STUB1MEN111556315254225 Affinity Capture-Western
STUB1MPP111556316169070 Two-hybrid
STUB1MPP111049416169070 Two-hybrid
STUB1MST1R11059216740632 Affinity Capture-Western; Biochemical Activity
STUB1MST1R11556316740632 Affinity Capture-Western; Biochemical Activity
STUB1NOS111090515466472 Affinity Capture-Western; Biochemical Activity
STUB1NOS111556315466472 Affinity Capture-Western; Biochemical Activity
STUB1PARK211110512150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1PARK211556312150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1RAF111556319011619 Affinity Capture-Western; Reconstituted Complex
STUB1RAF111183119011619 Affinity Capture-Western; Reconstituted Complex
STUB1ATXN111221716831871 Affinity Capture-Western; Biochemical Activity
STUB1ATXN111556316831871 Affinity Capture-Western; Biochemical Activity
STUB1SOD111253015358145 Affinity Capture-Western
STUB1SOD111556315358145 Affinity Capture-Western
STUB1TAL111274917962192 Affinity Capture-Western
STUB1TAL111556317962192 Affinity Capture-Western
STUB1TP5311556318223694 Affinity Capture-Western
STUB1TP5311301018223694 Affinity Capture-Western
STUB1UBC11556311743028 15358145 Affinity Capture-Western; Reconstituted Complex
STUB1UBC11316411743028 15358145 Affinity Capture-Western; Reconstituted Complex
STUB1UBA111556317873020 Reconstituted Complex
STUB1UBA111316517873020 Reconstituted Complex
STUB1UBE2D111556311557750 17873020 18485199 Reconstituted Complex
STUB1UBE2D111316911557750 17873020 18485199 Reconstituted Complex
STUB1UBE2D211556311676916 Reconstituted Complex
STUB1UBE2D211317011676916 Reconstituted Complex
STUB1UBE2D311556311743028 Reconstituted Complex
STUB1UBE2D311317111743028 Reconstituted Complex
STUB1UBE2E211556318485199 Reconstituted Complex
STUB1UBE2E211317318485199 Reconstituted Complex
STUB1UBE2N11556316307917 Reconstituted Complex
STUB1UBE2N11318216307917 Reconstituted Complex
STUB1UBE2V111556316307917 Reconstituted Complex
STUB1UBE2V111318316307917 Reconstituted Complex
STUB1VCP11556316621797 Affinity Capture-Western
STUB1VCP11325816621797 Affinity Capture-Western
STUB1AIMP211556316135753 Affinity Capture-Western
STUB1AIMP211368416135753 Affinity Capture-Western
STUB1BAG211556316169850 Reconstituted Complex
STUB1BAG211490816169850 Reconstituted Complex
STUB1STUB111556311743028 15538384 16714300 18485199 Affinity Capture-Western; Biochemical Activity
PARK7STUB111556315525661 Affinity Capture-Western
PARK7STUB111644615525661 Affinity Capture-Western
DNAJC13STUB111556315538384 Affinity Capture-MS
DNAJC13STUB111690815538384 Affinity Capture-MS
KHDRBS1STUB111556316169070 Two-hybrid
KHDRBS1STUB111590016169070 Two-hybrid
FBXO2STUB111556316682404 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FBXO2STUB111762316682404 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FBXO27STUB111556316682404 Reconstituted Complex
FBXO27STUB112599216682404 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891731
  • Data Attributes: MGI curated and HomoloGene calculated
No data