Gene Symbol:	STUB1 ( CHIP,HSPABP2,NY-CO-7,SDCCAG7,UBOX1 )
Gene Full Name:	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Band:	16p13.3
Quick Links	Entrez ID:10273; OMIM: 607207; Uniprot ID:CHIP_HUMAN; ENSEMBL ID: ENSG00000103266; HGNC ID: 11427
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000151	IDA	-	ubiquitin ligase complex	12150907
GO:0005654	IDA	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	10330192
GO:0005783	IDA	-	endoplasmic reticulum	12150907
GO:0005829	IDA	-	cytosol	-
GO:0005829	TAS	-	cytosol	-
GO:0030018	IEA	-	Z disc	-
GO:0031371	TAS	-	ubiquitin conjugating enzyme complex	16307917
GO:0042405	IDA	-	nuclear inclusion body	16831871
GO:0070062	IDA	-	extracellular exosome	23376485

GO ID	Evidence	Qualifier	GO_term	References
GO:0001664	IPI	-	G-protein coupled receptor binding	12150907
GO:0004842	IDA	-	ubiquitin-protein transferase activity	15466472
GO:0004842	IMP	-	ubiquitin-protein transferase activity	19713937
GO:0004842	TAS	-	ubiquitin-protein transferase activity	16307917
GO:0005515	IPI	-	protein binding	11146632
GO:0019899	IPI	-	enzyme binding	16280320
GO:0019900	IPI	-	kinase binding	17512523
GO:0030544	IDA	-	Hsp70 protein binding	10330192
GO:0030544	IPI	-	Hsp70 protein binding	24613385
GO:0030674	TAS	-	protein binding, bridging	16307917
GO:0030911	IDA	-	TPR domain binding	11146632
GO:0031625	IPI	-	ubiquitin protein ligase binding	12150907
GO:0034450	ISS	-	ubiquitin-ubiquitin ligase activity	-
GO:0042803	IDA	-	protein homodimerization activity	23990462
GO:0042803	ISS	-	protein homodimerization activity	-
GO:0046332	IDA	-	SMAD binding	15781469
GO:0046332	IPI	-	SMAD binding	24613385
GO:0051787	IDA	-	misfolded protein binding	16831871
GO:0051879	IDA	-	Hsp90 protein binding	11146632
GO:0061630	IDA	-	ubiquitin protein ligase activity	16275660
GO:0061630	IMP	-	ubiquitin protein ligase activity	16809764
GO:1904264	IMP	-	ubiquitin protein ligase activity involved in ERAD pathway	23990462

GO ID	Evidence	Qualifier	GO_term	References
GO:0000209	IDA	-	protein polyubiquitination	15781469
GO:0000209	IMP	-	protein polyubiquitination	19713937
GO:0006281	IEA	-	DNA repair	-
GO:0006511	IMP	-	ubiquitin-dependent protein catabolic process	19713937
GO:0006515	IDA	-	misfolded or incompletely synthesized protein catabolic process	16831871
GO:0016567	IDA	-	protein ubiquitination	16809764
GO:0016567	IMP	-	protein ubiquitination	16809764
GO:0030433	IEA	-	ubiquitin-dependent ERAD pathway	-
GO:0030512	IMP	-	negative regulation of transforming growth factor beta receptor signaling pathway	24613385
GO:0030512	TAS	-	negative regulation of transforming growth factor beta receptor signaling pathway	-
GO:0030579	IDA	-	ubiquitin-dependent SMAD protein catabolic process	15781469
GO:0030968	IEA	-	endoplasmic reticulum unfolded protein response	-
GO:0031398	IDA	-	positive regulation of protein ubiquitination	11146632
GO:0031647	IDA	-	regulation of protein stability	16809764
GO:0031943	IDA	-	regulation of glucocorticoid metabolic process	11146632
GO:0032091	IEA	-	negative regulation of protein binding	-
GO:0032436	IDA	-	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11146632
GO:0038128	TAS	-	ERBB2 signaling pathway	-
GO:0042787	IMP	-	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	23990462
GO:0043161	IDA	-	proteasome-mediated ubiquitin-dependent protein catabolic process	15781469
GO:0051443	IEA	-	positive regulation of ubiquitin-protein transferase activity	-
GO:0051604	TAS	-	protein maturation	16307917
GO:0051865	IDA	-	protein autoubiquitination	16307917
GO:0070534	IDA	-	protein K63-linked ubiquitination	16307917
GO:0071218	IDA	-	cellular response to misfolded protein	16831871
GO:0090035	IDA	-	positive regulation of chaperone-mediated protein complex assembly	16831871

Gene Symbol	Interactant	Interaction ID	References	Description
STUB1	AHR	106699	17209571	Affinity Capture-Western
STUB1	AHR	115563	17209571	Affinity Capture-Western
STUB1	AKT1	106710	18292230	Affinity Capture-Western
STUB1	AKT1	115563	18292230	Affinity Capture-Western
STUB1	XIAP	106828	19011619	Reconstituted Complex
STUB1	XIAP	115563	19011619	Reconstituted Complex
STUB1	BAG1	115563	11676916 15538384	Affinity Capture-Western; Reconstituted Complex
STUB1	BAG1	107049	11676916 15538384	Affinity Capture-Western; Reconstituted Complex
STUB1	RUNX2	107308	18541707	Affinity Capture-Western; Two-hybrid
STUB1	RUNX2	115563	18541707	Affinity Capture-Western; Two-hybrid
STUB1	CFTR	107506	15611333	Biochemical Activity
STUB1	CFTR	115563	15611333	Biochemical Activity
STUB1	CYP3A4	107948	19103148	Biochemical Activity
STUB1	CYP3A4	115563	19103148	Biochemical Activity
STUB1	EGFR	108276	20029029	PCA
STUB1	EGFR	115563	20029029	PCA
STUB1	EIF4E	108292	16720573	Affinity Capture-Western
STUB1	EIF4E	115563	16720573	Affinity Capture-Western
STUB1	ERBB2	108376	12239347	Affinity Capture-Western
STUB1	ERBB2	115563	12239347	Affinity Capture-Western
STUB1	ESR1	108403	15538384 16037132	Affinity Capture-Western; Reconstituted Complex
STUB1	ESR1	115563	15538384 16037132	Affinity Capture-Western; Reconstituted Complex
STUB1	GPR37	109119	12150907	Affinity Capture-Western
STUB1	GPR37	115563	12150907	Affinity Capture-Western
STUB1	GUCY1A2	109232	17873020	Affinity Capture-Western; Biochemical Activity
STUB1	GUCY1A2	115563	17873020	Affinity Capture-Western; Biochemical Activity
STUB1	HSPA1A	109535	10330192 12150907	Affinity Capture-Western; Reconstituted Complex
STUB1	HSPA1A	115563	10330192 12150907	Affinity Capture-Western; Reconstituted Complex
STUB1	HSPA4	109540	10330192 15538384 16169850	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1	HSPA4	115563	10330192 15538384 16169850	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1	HSPA8	109544	10330192 11557750 15538384	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
STUB1	HSPA8	115563	10330192 11557750 15538384	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
STUB1	HSP90AA1	109552	15538384 16307917 17324930	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1	HSP90AA1	115563	15538384 16307917 17324930	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1	DNAJB1	109569	10330192	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1	DNAJB1	115563	10330192	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STUB1	MAPT	110308	14962978 15447663 18292230	Affinity Capture-Western; Biochemical Activity
STUB1	MAPT	115563	14962978 15447663 18292230	Affinity Capture-Western; Biochemical Activity
STUB1	MCF2	115563	17178836	Reconstituted Complex
STUB1	MCF2	110336	17178836	Reconstituted Complex
STUB1	MAP3K5	115563	16038411 17595347	Affinity Capture-Western
STUB1	MAP3K5	110381	16038411 17595347	Affinity Capture-Western
STUB1	MEN1	110384	15254225	Affinity Capture-Western
STUB1	MEN1	115563	15254225	Affinity Capture-Western
STUB1	MPP1	115563	16169070	Two-hybrid
STUB1	MPP1	110494	16169070	Two-hybrid
STUB1	MST1R	110592	16740632	Affinity Capture-Western; Biochemical Activity
STUB1	MST1R	115563	16740632	Affinity Capture-Western; Biochemical Activity
STUB1	NOS1	110905	15466472	Affinity Capture-Western; Biochemical Activity
STUB1	NOS1	115563	15466472	Affinity Capture-Western; Biochemical Activity
STUB1	PARK2	111105	12150907	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1	PARK2	115563	12150907	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1	RAF1	115563	19011619	Affinity Capture-Western; Reconstituted Complex
STUB1	RAF1	111831	19011619	Affinity Capture-Western; Reconstituted Complex
STUB1	ATXN1	112217	16831871	Affinity Capture-Western; Biochemical Activity
STUB1	ATXN1	115563	16831871	Affinity Capture-Western; Biochemical Activity
STUB1	SOD1	112530	15358145	Affinity Capture-Western
STUB1	SOD1	115563	15358145	Affinity Capture-Western
STUB1	TAL1	112749	17962192	Affinity Capture-Western
STUB1	TAL1	115563	17962192	Affinity Capture-Western
STUB1	TP53	115563	18223694	Affinity Capture-Western
STUB1	TP53	113010	18223694	Affinity Capture-Western
STUB1	UBC	115563	11743028 15358145	Affinity Capture-Western; Reconstituted Complex
STUB1	UBC	113164	11743028 15358145	Affinity Capture-Western; Reconstituted Complex
STUB1	UBA1	115563	17873020	Reconstituted Complex
STUB1	UBA1	113165	17873020	Reconstituted Complex
STUB1	UBE2D1	115563	11557750 17873020 18485199	Reconstituted Complex
STUB1	UBE2D1	113169	11557750 17873020 18485199	Reconstituted Complex
STUB1	UBE2D2	115563	11676916	Reconstituted Complex
STUB1	UBE2D2	113170	11676916	Reconstituted Complex
STUB1	UBE2D3	115563	11743028	Reconstituted Complex
STUB1	UBE2D3	113171	11743028	Reconstituted Complex
STUB1	UBE2E2	115563	18485199	Reconstituted Complex
STUB1	UBE2E2	113173	18485199	Reconstituted Complex
STUB1	UBE2N	115563	16307917	Reconstituted Complex
STUB1	UBE2N	113182	16307917	Reconstituted Complex
STUB1	UBE2V1	115563	16307917	Reconstituted Complex
STUB1	UBE2V1	113183	16307917	Reconstituted Complex
STUB1	VCP	115563	16621797	Affinity Capture-Western
STUB1	VCP	113258	16621797	Affinity Capture-Western
STUB1	AIMP2	115563	16135753	Affinity Capture-Western
STUB1	AIMP2	113684	16135753	Affinity Capture-Western
STUB1	BAG2	115563	16169850	Reconstituted Complex
STUB1	BAG2	114908	16169850	Reconstituted Complex
STUB1	STUB1	115563	11743028 15538384 16714300 18485199	Affinity Capture-Western; Biochemical Activity
PARK7	STUB1	115563	15525661	Affinity Capture-Western
PARK7	STUB1	116446	15525661	Affinity Capture-Western
DNAJC13	STUB1	115563	15538384	Affinity Capture-MS
DNAJC13	STUB1	116908	15538384	Affinity Capture-MS
KHDRBS1	STUB1	115563	16169070	Two-hybrid
KHDRBS1	STUB1	115900	16169070	Two-hybrid
FBXO2	STUB1	115563	16682404	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FBXO2	STUB1	117623	16682404	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FBXO27	STUB1	115563	16682404	Reconstituted Complex
FBXO27	STUB1	125992	16682404	Reconstituted Complex

AutismKB 2.0

Annotation Details for STUB1