AutismKB 2.0

Annotation Details for DLC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DLC1 ( ARHGAP7,FLJ21120,HP,STARD12,p122-RhoGAP )
Gene Full Name: deleted in liver cancer 1
Band: 8p22
Quick LinksEntrez ID:10395; OMIM: 604258; Uniprot ID:RHG07_HUMAN; ENSEMBL ID: ENSG00000164741; HGNC ID: 2897
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus17888903
GO:0005737IDA-cytoplasm16951145
GO:0005829IDA-cytosol19158340
GO:0005829TAS-cytosol-
GO:0005901IDA-caveola16951145
GO:0005925IDA-focal adhesion16951145
GO:0030864IDA-cortical actin cytoskeleton19158340
GO:0032587IDA-ruffle membrane19158340
GO ID Evidence Qualifier GO_term References
GO:0005096IDA-GTPase activator activity17932950
GO:0005096IDANOTGTPase activator activity17932950
GO:0005096IMP-GTPase activator activity17888903
GO:0005096TAS-GTPase activator activity-
GO:0005515IPI-protein binding16951145
GO:0008289IEA-lipid binding-
GO:0042169IPI-SH2 domain binding17190795
GO ID Evidence Qualifier GO_term References
GO:0001843ISS-neural tube closure-
GO:0003007ISS-heart morphogenesis-
GO:0006915IDA-apoptotic process17292327
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process17888903
GO:0007165IEA-signal transduction-
GO:0008285IDA-negative regulation of cell proliferation12545165
GO:0008285IMP-negative regulation of cell proliferation17292327
GO:0008360IMP-regulation of cell shape17292327
GO:0021575ISS-hindbrain morphogenesis-
GO:0030036ISS-actin cytoskeleton organization-
GO:0030336IDA-negative regulation of cell migration17932950
GO:0030336IMP-negative regulation of cell migration17292327
GO:0030900ISS-forebrain development-
GO:0032956IMP-regulation of actin cytoskeleton organization17292327
GO:0035024IMP-negative regulation of Rho protein signal transduction16951145
GO:0035307IDA-positive regulation of protein dephosphorylation17292327
GO:0043547IEA-positive regulation of GTPase activity-
GO:0048041ISS-focal adhesion assembly-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0051497IDA-negative regulation of stress fiber assembly17932950
GO:0051895IDA-negative regulation of focal adhesion assembly19158340
GO:1900119IDA-positive regulation of execution phase of apoptosis17888903
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WWC1DLC111566716684779 Affinity Capture-Western; Reconstituted Complex
WWC1DLC111688416684779 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1354949
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved