AutismKB 2.0

Annotation Details for NDC80


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Basic Information Top
Gene Symbol:NDC80 ( HEC,HEC1,KNTC2,TID3,hsNDC80 )
Gene Full Name: NDC80 homolog, kinetochore complex component (S. cerevisiae)
Band: 18p11.32
Quick LinksEntrez ID:10403; OMIM: 607272; Uniprot ID:NDC80_HUMAN; ENSEMBL ID: ENSG00000080986; HGNC ID: 16909
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000775TAS-chromosome, centromeric region9315664
GO:0000776IDA-kinetochore17363900
GO:0000777IDA-condensed chromosome kinetochore14699129
GO:0000942IDA-condensed nuclear chromosome outer kinetochore18195732
GO:0005634TAS-nucleus9315664
GO:0005654IDA-nucleoplasm-
GO:0005813IDA-centrosome-
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO:0031262IDA-Ndc80 complex14699129
GO ID Evidence Qualifier GO_term References
GO:0005200IBA-structural constituent of cytoskeleton-
GO:0005515IPI-protein binding14699129
GO:0042802IPI-identical protein binding20360068
GO ID Evidence Qualifier GO_term References
GO:0000070TAS-mitotic sister chromatid segregation9315664
GO:0000132IMP-establishment of mitotic spindle orientation19468067
GO:0000278TAS-mitotic cell cycle9315664
GO:0007052IMP-mitotic spindle organization14699129
GO:0007059IMP-chromosome segregation14699129
GO:0007062TAS-sister chromatid cohesion-
GO:0008608IMP-attachment of spindle microtubules to kinetochore19468067
GO:0051301IEA-cell division-
GO:0051310IMP-metaphase plate congression25743205
GO:0051315IMP-attachment of mitotic spindle microtubules to kinetochore23891108
GO:0051383IMP-kinetochore organization22581055
GO:0090267IMP-positive regulation of mitotic cell cycle spindle assembly checkpoint25743205
GO:1905342IMP-positive regulation of protein localization to kinetochore22581055
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NDC80NEK21108269295362 12386167 Biochemical Activity; Reconstituted Complex; Two-hybrid
NDC80NEK21156759295362 12386167 Biochemical Activity; Reconstituted Complex; Two-hybrid
NDC80PSMC21116749295362 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
NDC80PSMC21156759295362 Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
NDC80TOM1L111535216169070 Two-hybrid
NDC80TOM1L111567516169070 Two-hybrid
SPC24NDC8011567514699129 Affinity Capture-MS
SPC24NDC8012709314699129 Affinity Capture-MS
NUF2NDC8011567514699129 Affinity Capture-MS
NUF2NDC8012367314699129 Affinity Capture-MS
SPC25NDC8012150714699129 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SPC25NDC8011567514699129 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
MIS12NDC8012247415371340 15502821 Affinity Capture-MS
MIS12NDC8011567515371340 15502821 Affinity Capture-MS
PLDNNDC8011764416189514 Two-hybrid
PLDNNDC8011567516189514 Two-hybrid
CCDC53NDC8011922516189514 Two-hybrid
CCDC53NDC8011567516189514 Two-hybrid
AMOTL2NDC8011953016189514 Two-hybrid
AMOTL2NDC8011567516189514 Two-hybrid
CALCOCO1NDC8012169216189514 Two-hybrid
CALCOCO1NDC8011567516189514 Two-hybrid
KLHL12NDC8012189016189514 Two-hybrid
KLHL12NDC8011567516189514 Two-hybrid
USHBP1NDC8012379116189514 Two-hybrid
USHBP1NDC8011567516189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1914302
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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