AutismKB 2.0

Annotation Details for RAPGEF3


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Basic Information Top
Gene Symbol:RAPGEF3 ( CAMP-GEFI,EPAC,EPAC1,HSU79275,MGC21410,bcm910 )
Gene Full Name: Rap guanine nucleotide exchange factor (GEF) 3
Band: 12q13.11
Quick LinksEntrez ID:10411; OMIM: 606057; Uniprot ID:A8K2G5_HUMAN; ENSEMBL ID: ENSG00000079337; HGNC ID: 16629
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDAcolocalizes_withplasma membrane21047789
GO:0005886TAS-plasma membrane-
GO:0005902IDA-microvillus21047789
GO:0012505IEA-endomembrane system-
GO:0016020TAS-membrane10777494
GO:0030027IDA-lamellipodium21047789
GO:0030175IDA-filopodium21047789
GO:0030864IDAcolocalizes_withcortical actin cytoskeleton21047789
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0005085EXP-guanyl-nucleotide exchange factor activity15334074
GO:0005515IPI-protein binding21393242
GO:0017034IMP-Rap guanyl-nucleotide exchange factor activity21840392
GO:0019904IPI-protein domain specific binding21047789
GO:0030552IEA-cAMP binding-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0007165TAS-signal transduction9853756
GO:0008283TAS-cell proliferation9853756
GO:0019933NAS-cAMP-mediated signaling16177794
GO:0030822NAS-positive regulation of cAMP catabolic process16177794
GO:0032486IMP-Rap protein signal transduction21840392
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation23867755
GO:0034242IMP-negative regulation of syncytium formation by plasma membrane fusion23867755
GO:0043547IMP-positive regulation of GTPase activity21840392
GO:0045766IMP-positive regulation of angiogenesis21393242
GO:0046827IDA-positive regulation of protein export from nucleus23867755
GO:0050796TAS-regulation of insulin secretion-
GO:0051496IMP-positive regulation of stress fiber assembly21840392
GO:0060143IMP-positive regulation of syncytium formation by plasma membrane fusion23867755
GO:0061028IMP-establishment of endothelial barrier21840392
GO:0071320IDA-cellular response to cAMP21840392
GO:1901985IMP-positive regulation of protein acetylation23867755
GO:2000249IMP-regulation of actin cytoskeleton reorganization21840392
GO:2000615IMPNOTregulation of histone H3-K9 acetylation23867755
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAPGEF3RAP1A11184110777494 Biochemical Activity
RAPGEF3RAP1A11568210777494 Biochemical Activity
RAPGEF3RAP2A11184610777494 Biochemical Activity
RAPGEF3RAP2A11568210777494 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2441741
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090312-38'