AutismKB 2.0

Annotation Details for YAP1


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Basic Information Top
Gene Symbol:YAP1 ( YAP,YAP2,YAP65,YKI )
Gene Full Name: Yes-associated protein 1
Band: 11q22.1
Quick LinksEntrez ID:10413; OMIM: 606608; Uniprot ID:YAP1_HUMAN; ENSEMBL ID: ENSG00000137693; HGNC ID: 16262
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus17974916
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm17974916
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO:0071148IDA-TEAD-1-YAP complex20123905
GO:0071149IDA-TEAD-2-YAP complex20368466
GO ID Evidence Qualifier GO_term References
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0001076IEA-transcription factor activity, RNA polymerase II transcription factor binding-
GO:0003682IEA-chromatin binding-
GO:0003713IDA-transcription coactivator activity18158288
GO:0003713IMP-transcription coactivator activity20123905
GO:0003714IDA-transcription corepressor activity18158288
GO:0005515IPI-protein binding7644498
GO:0008022IEA-protein C-terminus binding-
GO:0033613IPI-activating transcription factor binding20123905
GO:0044212IDA-transcription regulatory region DNA binding18280240
GO:0046982IPI-protein heterodimerization activity20123905
GO:0070064IEA-proline-rich region binding-
GO ID Evidence Qualifier GO_term References
GO:0000902IEA-cell morphogenesis-
GO:0001570IEA-vasculogenesis-
GO:0003143IEA-embryonic heart tube morphogenesis-
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006461IDA-protein complex assembly20368466
GO:0006461IMP-protein complex assembly20123905
GO:0006974IDA-cellular response to DNA damage stimulus18280240
GO:0008283IDA-cell proliferation17974916
GO:0008284IEA-positive regulation of cell proliferation-
GO:0010837IEA-regulation of keratinocyte proliferation-
GO:0030216IEA-keratinocyte differentiation-
GO:0030857IEA-negative regulation of epithelial cell differentiation-
GO:0030903IEA-notochord development-
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035329TAS-hippo signaling18158288
GO:0045893IDA-positive regulation of transcription, DNA-templated20368466
GO:0045893IMP-positive regulation of transcription, DNA-templated20123905
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046622IEA-positive regulation of organ growth-
GO:0048339IEA-paraxial mesoderm development-
GO:0048368IEA-lateral mesoderm development-
GO:0050767IDA-regulation of neurogenesis25433207
GO:0060242IDA-contact inhibition17974916
GO:0060449IEA-bud elongation involved in lung branching-
GO:0060487IEA-lung epithelial cell differentiation-
GO:0071300IEA-cellular response to retinoic acid-
GO:0071480IDA-cellular response to gamma radiation18280240
GO:0072091IDA-regulation of stem cell proliferation25433207
GO:0072307IEA-regulation of metanephric nephron tubule epithelial cell differentiation-
GO:0090263IEA-positive regulation of canonical Wnt signaling pathway-
GO:1902459IEA-positive regulation of stem cell population maintenance-
GO:1903507IEA-negative regulation of nucleic acid-templated transcription-
GO:2000737IEA-negative regulation of stem cell differentiation-
GO:2001237IEA-negative regulation of extrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
YAP1RUNX210730810228168 Reconstituted Complex
YAP1RUNX211568410228168 Reconstituted Complex
YAP1RUNX110730910228168 Two-hybrid
YAP1RUNX111568410228168 Two-hybrid
YAP1RUNX310731210228168 Reconstituted Complex
YAP1RUNX311568410228168 Reconstituted Complex
YAP1EP30010834715893728 Co-localization
YAP1EP30011568415893728 Co-localization
YAP1ERBB411568415023535 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YAP1ERBB410837815023535 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YAP1KIF5A11568411278422 Two-hybrid
YAP1KIF5A10999911278422 Two-hybrid
YAP1SMAD611026612118366 Affinity Capture-Western
YAP1SMAD611568412118366 Affinity Capture-Western
YAP1SMAD711568412118366 Affinity Capture-Western; Phenotypic Enhancement; Two-hybrid
YAP1SMAD711026712118366 Affinity Capture-Western; Phenotypic Enhancement; Two-hybrid
YAP1TP53BP211301211278422 Reconstituted Complex; Two-hybrid
YAP1TP53BP211568411278422 Reconstituted Complex; Two-hybrid
YAP1TP7311301411278685 15893728 17110958 Affinity Capture-Western; Reconstituted Complex
YAP1TP7311568411278685 15893728 17110958 Affinity Capture-Western; Reconstituted Complex
YAP1TP6311418111278685 Reconstituted Complex
YAP1TP6311568411278685 Reconstituted Complex
YAP1SLC9A3R111476910562288 Affinity Capture-Western; Reconstituted Complex
YAP1SLC9A3R111568410562288 Affinity Capture-Western; Reconstituted Complex
YAP1SCAMP311537819158374 Two-hybrid
YAP1SCAMP311568419158374 Two-hybrid
DENND3YAP111656211278422 Two-hybrid
DENND3YAP111568411278422 Two-hybrid
WBP1YAP111710311604498 Protein-peptide
WBP1YAP111568411604498 Protein-peptide
YWHAQYAP111616812535517 Affinity Capture-MS
YWHAQYAP111568412535517 Affinity Capture-MS
ITCHYAP112374717110958 Affinity Capture-Western
ITCHYAP111568417110958 Affinity Capture-Western
AMOTYAP112755719615732 Affinity Capture-MS
AMOTYAP111568419615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103262
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-9710'